About the Authors

Xiaoxuan Zhang

Contributed equally to this work with: Xiaoxuan Zhang, Risheng Cao

Affiliations Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P.R.China, Department of Microbiology & Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America

Risheng Cao

Contributed equally to this work with: Xiaoxuan Zhang, Risheng Cao

Affiliation Department of Microbiology & Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America

Runping Liu

Affiliations Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P.R.China, Department of Microbiology & Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America

Renping Zhao

Affiliation Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P.R.China

Yi Huang

Affiliations Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P.R.China, School of Pharmacy, Wenzhou Medical University, Wenzhou, P.R.China

Emily C. Gurley

Affiliation Department of Microbiology & Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America

Phillip B. Hylemon

Affiliations Department of Microbiology & Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America, Department of Internal Medicine/Gastroenterology and McGuire Veterans Affairs Medical Center, Richmond, Virginia, United States of America

William M. Pandak

Affiliation Department of Internal Medicine/Gastroenterology and McGuire Veterans Affairs Medical Center, Richmond, Virginia, United States of America

Guangji Wang

wangguangji01@gmail.com (GW); hzhou@vcu.edu (HZ)

Affiliation Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P.R.China

Luyong Zhang

Affiliation Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P.R.China

Xiaokun Li

Affiliation School of Pharmacy, Wenzhou Medical University, Wenzhou, P.R.China

Huiping Zhou

wangguangji01@gmail.com (GW); hzhou@vcu.edu (HZ)

Affiliations Department of Microbiology & Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America, School of Pharmacy, Wenzhou Medical University, Wenzhou, P.R.China, Department of Internal Medicine/Gastroenterology and McGuire Veterans Affairs Medical Center, Richmond, Virginia, United States of America

Competing Interests

This study is supported by Merck Research Fund. This does not alter the authors’ adherence to PLOS ONE polices on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PH WP HZ. Performed the experiments: XZ RC RL RZ YH EG. Analyzed the data: HZ XL GW LZ. Wrote the paper: PH WP GW LZ XL HZ.