Purine Analog-Like Properties of Bendamustine Underlie Rapid Activation of DNA Damage Response and Synergistic Effects with Pyrimidine Analogues in Lymphoid Malignancies

• Nobuya Hiraoka,

  Affiliation Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan

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• Jiro Kikuchi,

  Affiliation Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan

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• Takahiro Yamauchi,

  Affiliation Division of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui, Japan

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• Daisuke Koyama,

  Affiliation Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan

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• Taeko Wada,

  Affiliation Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan

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• Mitsuyo Uesawa,

  Affiliation Department of Hematology, Tochigi Cancer Center, Utsunomiya, Tochigi, Japan

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• Miyuki Akutsu,

  Affiliation Department of Hematology, Tochigi Cancer Center, Utsunomiya, Tochigi, Japan

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• Shigehisa Mori,

  Affiliation Medical Education Center, Saitama Medical University, Moroyama, Saitama, Japan

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• Yuichi Nakamura,

  Affiliation Department of Hematology, Saitama Medical University, Moroyama, Saitama, Japan

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• Takanori Ueda,

  Affiliation Division of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui, Japan

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• Yasuhiko Kano,

  Affiliation Department of Hematology, Tochigi Cancer Center, Utsunomiya, Tochigi, Japan

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• Yusuke Furukawa

  * E-mail: furuyu@jichi.ac.jp

  Affiliation Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan

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