About the Authors

Nobuya Hiraoka

Affiliation Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan

Jiro Kikuchi

Affiliation Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan

Takahiro Yamauchi

Affiliation Division of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui, Japan

Daisuke Koyama

Affiliation Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan

Taeko Wada

Affiliation Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan

Mitsuyo Uesawa

Affiliation Department of Hematology, Tochigi Cancer Center, Utsunomiya, Tochigi, Japan

Miyuki Akutsu

Affiliation Department of Hematology, Tochigi Cancer Center, Utsunomiya, Tochigi, Japan

Shigehisa Mori

Affiliation Medical Education Center, Saitama Medical University, Moroyama, Saitama, Japan

Yuichi Nakamura

Affiliation Department of Hematology, Saitama Medical University, Moroyama, Saitama, Japan

Takanori Ueda

Affiliation Division of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui, Japan

Yasuhiko Kano

Affiliation Department of Hematology, Tochigi Cancer Center, Utsunomiya, Tochigi, Japan

Yusuke Furukawa

furuyu@jichi.ac.jp

Affiliation Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan

Competing Interests

The authors would like to declare the following: Y.F. received research funding from Eisai Co., Janssen Pharmaceutical K.K., and Novartis Pharmaceuticals Co. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: NH JK YK YF. Performed the experiments: NH JK TY DK TW MU MA YK YF. Analyzed the data: NH JK TY DK TW TU YK YF. Contributed reagents/materials/analysis tools: SM YN. Wrote the paper: NH JK TY TU YK YF.