Familial Young-Onset Diabetes, Pre-Diabetes and Cardiovascular Disease Are Associated with Genetic Variants of DACH1 in Chinese

• Ronald Ching Wan Ma ,

  Contributed equally to this work with: Ronald Ching Wan Ma, Heung Man Lee, Vincent Kwok Lim Lam

  Affiliations Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China, Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, People’s Republic of China, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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• Heung Man Lee ,

  Contributed equally to this work with: Ronald Ching Wan Ma, Heung Man Lee, Vincent Kwok Lim Lam

  Affiliations Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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• Vincent Kwok Lim Lam ,

  Contributed equally to this work with: Ronald Ching Wan Ma, Heung Man Lee, Vincent Kwok Lim Lam

  Affiliations Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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• Claudia Ha Ting Tam,

  Affiliation Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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• Janice Siu Ka Ho,

  Affiliation Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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• Hai-Lu Zhao,

  Affiliation Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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• Jing Guan,

  Affiliation Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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• Alice Pik Shan Kong,

  Affiliations Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China, Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, People’s Republic of China, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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• Eric Lau,

  Affiliation Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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• Guozhi Zhang,

  Affiliation Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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• Andrea Luk,

  Affiliation Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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• Ying Wang,

  Affiliation Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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• Stephen Kwok Wing Tsui,

  Affiliation School of Biomedical Science, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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• Ting Fung Chan,

  Affiliation School of Life Science, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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• Cheng Hu,

  Affiliation Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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• Wei Ping Jia,

  Affiliation Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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• Kyong Soo Park,

  Affiliation Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and Department of Internal Medicine, College of Medicine, Seoul National University, Chongno-gu, Seoul, Korea

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• Hong Kyu Lee,

  Current address: Department of Internal Medicine, Eulji University, Hangeulbiseok-gil, Hagye-dong, Nowon-gu, Seoul, Korea

  Affiliation Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and Department of Internal Medicine, College of Medicine, Seoul National University, Chongno-gu, Seoul, Korea

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• Hiroto Furuta,

  Affiliation First Department of Medicine, Wakayama Medical University, Wakayama, Japan

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• Kishio Nanjo,

  Affiliation First Department of Medicine, Wakayama Medical University, Wakayama, Japan

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• E. Shyong Tai,

  Affiliation Department of Epidemiology and Public Health, National University of Singapore, Singapore, Singapore

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• Daniel Peng-Keat Ng,

  Affiliation Department of Epidemiology and Public Health, National University of Singapore, Singapore, Singapore

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• Nelson Leung Sang Tang,

  Affiliations Department of Chemical Pathology, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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• Jean Woo,

  Affiliation Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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• Ping Chung Leung,

  Affiliation Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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• Hong Xue,

  Affiliation Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong SAR, People’s Republic of China

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• Jeffrey Wong,

  Affiliation Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong SAR, People’s Republic of China

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• Po Sing Leung,

  Affiliation School of Biomedical Science, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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• Terrence C. K. Lau,

  Current address: Department of Biology and Chemistry, City University of Hong Kong, Hong Kong SAR, People’s Republic of China

  Affiliation School of Biomedical Science, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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• Peter Chun Yip Tong,

  Affiliations Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China, Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, People’s Republic of China

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• Gang Xu,

  Affiliations Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China, Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, People’s Republic of China, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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• Maggie Chor Yin Ng,

  Current address: Center for Diabetes Research, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America.

  Affiliation Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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• Wing Yee So,

  Affiliations Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China, Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, People’s Republic of China, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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•  [ ... ],
• Juliana Chung Ngor Chan

  * E-mail: jchan@cuhk.edu.hk

  Affiliations Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China, Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, People’s Republic of China, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

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