Small Angle X-Ray Scattering Studies of Mitochondrial Glutaminase C Reveal Extended Flexible Regions, and Link Oligomeric State with Enzyme Activity

• Magda Møller,

  Affiliation Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark

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• Søren S. Nielsen,

  Affiliations Department of Structural Biophysics, University of Copenhagen, Copenhagen, Denmark, Cornell High Energy Synchrotron Source (CHESS) and Macromolecular Diffraction Facility at CHESS (MacCHESS), Cornell University, Ithaca, New York, United States of America

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• Sekar Ramachandran,

  Affiliation Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, United States of America

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• Yuxing Li,

  Affiliation Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, United States of America

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• Giancarlo Tria,

  Affiliations European Molecular Biology Laboratory, Hamburg Outstation c/o DESY, Hamburg, Germany, Center for Bioinformatics, University of Hamburg, Hamburg, Germany

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• Werner Streicher,

  Affiliation Protein Function and Interactions, Novo Nordisk Foundation Center for Protein Research, Copenhagen, Denmark

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• Maxim V. Petoukhov,

  Affiliation European Molecular Biology Laboratory, Hamburg Outstation c/o DESY, Hamburg, Germany

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• Richard A. Cerione,

  Affiliations Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, United States of America, Department of Molecular Medicine, Cornell University, Ithaca, New York, United States of America

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• Richard E. Gillilan,

  Affiliation Cornell High Energy Synchrotron Source (CHESS) and Macromolecular Diffraction Facility at CHESS (MacCHESS), Cornell University, Ithaca, New York, United States of America

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• Bente Vestergaard

  * E-mail: bente.vestergaard@sund.ku.dk

  Affiliation Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark

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