Tectorigenin Attenuates Palmitate-Induced Endothelial Insulin Resistance via Targeting ROS-Associated Inflammation and IRS-1 Pathway

Qi Wang; Xiao-Lan Cheng; Dong-Yan Zhang; Xue-Jiao Gao; Ling Zhou; Xiao-Ying Qin; Guo-Yong Xie; Kang Liu; Yong Qin; Bao-Lin Liu; Min-Jian Qin

doi:10.1371/journal.pone.0066417

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Open Access

Peer-reviewed

Research Article

Tectorigenin Attenuates Palmitate-Induced Endothelial Insulin Resistance via Targeting ROS-Associated Inflammation and IRS-1 Pathway

Qi Wang ,

Contributed equally to this work with: Qi Wang, Xiao-Lan Cheng

Affiliation Department of Resource Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China
⨯
Xiao-Lan Cheng ,

Contributed equally to this work with: Qi Wang, Xiao-Lan Cheng

Affiliation Department of Resource Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China
⨯
Dong-Yan Zhang,

Affiliation Department of Pharmacy, Henan Provincial People's Hospital, Zhengzhou, China
⨯
Xue-Jiao Gao,

Affiliation State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, China
⨯
Ling Zhou,

Affiliation Department of Resource Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China
⨯
Xiao-Ying Qin,

Affiliation Department of Resource Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China
⨯
Guo-Yong Xie,

Affiliation Department of Resource Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China
⨯
Kang Liu,

Affiliation Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China
⨯
Yong Qin,

Affiliation Department of Resource Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China
⨯
Bao-Lin Liu,

Affiliation Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China
⨯
Min-Jian Qin

* E-mail: minjianqin@163.com

Affiliation Department of Resource Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China
⨯

Tectorigenin Attenuates Palmitate-Induced Endothelial Insulin Resistance via Targeting ROS-Associated Inflammation and IRS-1 Pathway

Qi Wang,
Xiao-Lan Cheng,
Dong-Yan Zhang,
Xue-Jiao Gao,
Ling Zhou,
Xiao-Ying Qin,
Guo-Yong Xie,
Kang Liu,
Yong Qin,
Bao-Lin Liu

Published: June 19, 2013
https://doi.org/10.1371/journal.pone.0066417

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