About the Authors

Qi Wang

Contributed equally to this work with: Qi Wang, Xiao-Lan Cheng

Affiliation Department of Resource Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China

Xiao-Lan Cheng

Contributed equally to this work with: Qi Wang, Xiao-Lan Cheng

Affiliation Department of Resource Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China

Dong-Yan Zhang

Affiliation Department of Pharmacy, Henan Provincial People's Hospital, Zhengzhou, China

Xue-Jiao Gao

Affiliation State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, China

Ling Zhou

Affiliation Department of Resource Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China

Xiao-Ying Qin

Affiliation Department of Resource Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China

Guo-Yong Xie

Affiliation Department of Resource Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China

Kang Liu

Affiliation Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China

Yong Qin

Affiliation Department of Resource Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China

Bao-Lin Liu

Affiliation Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China

Min-Jian Qin

minjianqin@163.com

Affiliation Department of Resource Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China

Competing Interests

Dr. Yong Qin, who is a professor at China Pharmaceutical University, receives compensation as a consultant for commercial company Jiangsu Honghui Medical Co., Ltd. He contributes to this paper on the manuscript writing and experimental guidance. There is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in this manuscript. This does not alter the authors' adherence to all of the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: QW DYZ XJG KL BLL MJQ. Performed the experiments: QW XLC DYZ XJG LZ XYQ YQ. Analyzed the data: QW XLC DYZ XJG BLL. Contributed reagents/materials/analysis tools: QW XLC DYZ XJG BLL. Wrote the paper: QW XLC YQ BLL MJQ. Revised the manuscript: XLC GYX.