High Concentrations of L-Ascorbic Acid Specifically Inhibit the Growth of Human Leukemic Cells via Downregulation of HIF-1α Transcription

Hiroshi Kawada; Mitsuyo Kaneko; Masakazu Sawanobori; Tomoko Uno; Hideyuki Matsuzawa; Yoshihiko Nakamura; Hiromichi Matsushita; Kiyoshi Ando

doi:10.1371/journal.pone.0062717

Loading metrics

Open Access

Peer-reviewed

Research Article

High Concentrations of L-Ascorbic Acid Specifically Inhibit the Growth of Human Leukemic Cells via Downregulation of HIF-1α Transcription

Hiroshi Kawada ,

Contributed equally to this work with: Hiroshi Kawada, Mitsuyo Kaneko

* E-mail: hkawada@is.icc.u-tokai.ac.jp

Affiliations Division of Hematology/Oncology, Department of Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan, Research Center for Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
⨯
Mitsuyo Kaneko ,

Contributed equally to this work with: Hiroshi Kawada, Mitsuyo Kaneko

Affiliations Division of Hematology/Oncology, Department of Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan, Research Center for Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
⨯
Masakazu Sawanobori,

Affiliation Division of Hematology/Oncology, Department of Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
⨯
Tomoko Uno,

Affiliation Research Center for Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
⨯
Hideyuki Matsuzawa,

Affiliation Research Center for Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
⨯
Yoshihiko Nakamura,

Affiliation Research Center for Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
⨯
Hiromichi Matsushita,

Affiliations Research Center for Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan, Department of Laboratory Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
⨯
Kiyoshi Ando

Affiliations Division of Hematology/Oncology, Department of Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan, Research Center for Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
⨯

High Concentrations of L-Ascorbic Acid Specifically Inhibit the Growth of Human Leukemic Cells via Downregulation of HIF-1α Transcription

Hiroshi Kawada,
Mitsuyo Kaneko,
Masakazu Sawanobori,
Tomoko Uno,
Hideyuki Matsuzawa,
Yoshihiko Nakamura,
Hiromichi Matsushita,
Kiyoshi Ando

Published: April 23, 2013
https://doi.org/10.1371/journal.pone.0062717

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Leukemia
Is the Subject Area "Leukemia" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
HL60 cells
Is the Subject Area "HL60 cells" applicable to this article?

Thanks for your feedback.
Transcription factors
Is the Subject Area "Transcription factors" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Catalases
Is the Subject Area "Catalases" applicable to this article?

Thanks for your feedback.
Malignant tumors
Is the Subject Area "Malignant tumors" applicable to this article?

Thanks for your feedback.