Mutations in Mll2, an H3K4 Methyltransferase, Result in Insulin Resistance and Impaired Glucose Tolerance in Mice

Michelle Goldsworthy; Nathan L. Absalom; David Schröter; Helen C. Matthews; Debora Bogani; Lee Moir; Anna Long; Christopher Church; Alison Hugill; Quentin M. Anstee; Rob Goldin; Mark Thursz; Florian Hollfelder; Roger D. Cox

doi:10.1371/journal.pone.0061870

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Open Access

Peer-reviewed

Research Article

Mutations in Mll2, an H3K4 Methyltransferase, Result in Insulin Resistance and Impaired Glucose Tolerance in Mice

Michelle Goldsworthy ,

Contributed equally to this work with: Michelle Goldsworthy, Nathan L. Absalom

* E-mail: m.goldsworthy@har.mrc.ac.uk

Affiliation Medical Research Council (MRC) Harwell, Diabetes Group, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom
⨯
Nathan L. Absalom ,

Contributed equally to this work with: Michelle Goldsworthy, Nathan L. Absalom

Affiliation Medical Research Council (MRC) Harwell, Diabetes Group, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom
⨯
David Schröter,

Affiliation Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
⨯
Helen C. Matthews,

Affiliations Medical Research Council (MRC) Harwell, Diabetes Group, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom, Department of Academic Medicine, St Mary's Hospital Campus, Imperial College London, United Kingdom
⨯
Debora Bogani,

Affiliation Medical Research Council (MRC) Harwell, Diabetes Group, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom
⨯
Lee Moir,

Affiliation Medical Research Council (MRC) Harwell, Diabetes Group, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom
⨯
Anna Long,

Affiliation Medical Research Council (MRC) Harwell, Diabetes Group, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom
⨯
Christopher Church,

Affiliation Medical Research Council (MRC) Harwell, Diabetes Group, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom
⨯
Alison Hugill,

Affiliation Medical Research Council (MRC) Harwell, Diabetes Group, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom
⨯
Quentin M. Anstee,

Affiliations Medical Research Council (MRC) Harwell, Diabetes Group, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom, Institute of Cellular Medicine, Newcastle University, The Medical School, Framlington Place, Newcastle-upon-Tyne, United Kingdom
⨯
Rob Goldin,

Affiliation Department of Histopathology, Imperial College London, St Mary's Hospital Campus, London, United Kingdom
⨯
Mark Thursz,

Affiliation Department of Academic Medicine, St Mary's Hospital Campus, Imperial College London, United Kingdom
⨯
Florian Hollfelder,

Affiliation Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
⨯
Roger D. Cox

Affiliation Medical Research Council (MRC) Harwell, Diabetes Group, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom
⨯

Mutations in Mll2, an H3K4 Methyltransferase, Result in Insulin Resistance and Impaired Glucose Tolerance in Mice

Michelle Goldsworthy,
Nathan L. Absalom,
David Schröter,
Helen C. Matthews,
Debora Bogani,
Lee Moir,
Anna Long,
Christopher Church,
Alison Hugill,
Quentin M. Anstee

Published: June 24, 2013
https://doi.org/10.1371/journal.pone.0061870

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Genetically modified animals
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Heterozygosity
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Methyltransferases
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