A Frequent PNPLA3 Variant Is a Sex Specific Disease Modifier in PSC Patients with Bile Duct Stenosis

• Kilian Friedrich ,

  Contributed equally to this work with: Kilian Friedrich, Christian Rupp

  Affiliation Department of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Baden-Wuerttemberg, Germany

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• Christian Rupp ,

  Contributed equally to this work with: Kilian Friedrich, Christian Rupp

  Affiliation Department of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Baden-Wuerttemberg, Germany

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• Johannes Roksund Hov,

  Affiliations Norwegian PSC Research Center, Research Institute for Internal Medicine and Department of Gastroenterology, Division for Cancer, Surgery and Transplantation, Oslo University Hospital, Oslo, Norway, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway

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• Niels Steinebrunner,

  Affiliation Department of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Baden-Wuerttemberg, Germany

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• Karl-Heinz Weiss,

  Affiliation Department of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Baden-Wuerttemberg, Germany

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• Adolf Stiehl,

  Affiliation Department of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Baden-Wuerttemberg, Germany

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• Maik Brune,

  Affiliation Department of Internal Medicine I, University Hospital of Heidelberg, Heidelberg, Baden-Wuerttemberg, Germany

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• Petra Kloeters Yvonne Schaefer,
• Peter Schemmer,

  Affiliation Department of General Surgery, University Hospital of Heidelberg, Heidelberg, Baden-Wuerttemberg, Germany

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• Peter Sauer,

  Affiliation Department of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Baden-Wuerttemberg, Germany

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• Peter Schirmacher,

  Affiliation Institute of Pathology, University Hospital of Heidelberg, Heidelberg, Baden-Wuerttemberg, Germany

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• Heiko Runz,

  Affiliation Institute of Human Genetics, University Hospital of Heidelberg, Heidelberg, Baden-Wuerttemberg, Germany

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• Tom Hemming Karlsen,

  Affiliations Norwegian PSC Research Center, Research Institute for Internal Medicine and Department of Gastroenterology, Division for Cancer, Surgery and Transplantation, Oslo University Hospital, Oslo, Norway, Institute of Medicine, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway

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• Wolfgang Stremmel,

  Affiliation Department of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Baden-Wuerttemberg, Germany

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• Daniel Nils Gotthardt

  * E-mail: Daniel.Gotthardt@med.uni-heidelberg.de

  Affiliation Department of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Baden-Wuerttemberg, Germany

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