Phenytoin Inhibits the Persistent Sodium Current in Neocortical Neurons by Modifying Its Inactivation Properties

Open Access

Peer-reviewed

Research Article

Elisa Colombo,

Affiliation Department of Neurophysiopathology – Epilepsy Center, Foundation IRCCS Neurological Institute C. Besta, Milan, Italy
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Silvana Franceschetti,

Affiliation Department of Neurophysiopathology – Epilepsy Center, Foundation IRCCS Neurological Institute C. Besta, Milan, Italy
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Giuliano Avanzini,

Affiliation Department of Neurophysiopathology – Epilepsy Center, Foundation IRCCS Neurological Institute C. Besta, Milan, Italy
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Massimo Mantegazza

* E-mail: mantegazza@ipmc.cnrs.fr

Affiliations Department of Neurophysiopathology – Epilepsy Center, Foundation IRCCS Neurological Institute C. Besta, Milan, Italy, Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), CNRS UMR7275 and University of Nice-Sophia Antipolis, Valbonne, France
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Neurons
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Membrane potential
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Curve fitting
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Action potentials
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Kinetics
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Evoked potentials
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Drug therapy
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