Phenytoin Inhibits the Persistent Sodium Current in Neocortical Neurons by Modifying Its Inactivation Properties

Elisa Colombo; Silvana Franceschetti; Giuliano Avanzini; Massimo Mantegazza

doi:10.1371/journal.pone.0055329

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Open Access

Peer-reviewed

Research Article

Phenytoin Inhibits the Persistent Sodium Current in Neocortical Neurons by Modifying Its Inactivation Properties

Elisa Colombo,

Affiliation Department of Neurophysiopathology – Epilepsy Center, Foundation IRCCS Neurological Institute C. Besta, Milan, Italy
⨯
Silvana Franceschetti,

Affiliation Department of Neurophysiopathology – Epilepsy Center, Foundation IRCCS Neurological Institute C. Besta, Milan, Italy
⨯
Giuliano Avanzini,

Affiliation Department of Neurophysiopathology – Epilepsy Center, Foundation IRCCS Neurological Institute C. Besta, Milan, Italy
⨯
Massimo Mantegazza

* E-mail: mantegazza@ipmc.cnrs.fr

Affiliations Department of Neurophysiopathology – Epilepsy Center, Foundation IRCCS Neurological Institute C. Besta, Milan, Italy, Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), CNRS UMR7275 and University of Nice-Sophia Antipolis, Valbonne, France
⨯

Phenytoin Inhibits the Persistent Sodium Current in Neocortical Neurons by Modifying Its Inactivation Properties

Elisa Colombo,
Silvana Franceschetti,
Giuliano Avanzini,
Massimo Mantegazza

Published: January 29, 2013
https://doi.org/10.1371/journal.pone.0055329

About the Authors

Elisa Colombo

Affiliation Department of Neurophysiopathology – Epilepsy Center, Foundation IRCCS Neurological Institute C. Besta, Milan, Italy

Silvana Franceschetti

Affiliation Department of Neurophysiopathology – Epilepsy Center, Foundation IRCCS Neurological Institute C. Besta, Milan, Italy

Giuliano Avanzini

Affiliation Department of Neurophysiopathology – Epilepsy Center, Foundation IRCCS Neurological Institute C. Besta, Milan, Italy

Massimo Mantegazza

* E-mail: mantegazza@ipmc.cnrs.fr

Affiliations Department of Neurophysiopathology – Epilepsy Center, Foundation IRCCS Neurological Institute C. Besta, Milan, Italy, Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), CNRS UMR7275 and University of Nice-Sophia Antipolis, Valbonne, France

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MM SF. Performed the experiments: EC. Analyzed the data: EC MM SF. Wrote the paper: MM SF GA.

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Neurons
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Membrane potential
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Depolarization
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Curve fitting
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Action potentials
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Kinetics
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Evoked potentials
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Drug therapy
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