A Natural Small Molecule Harmine Inhibits Angiogenesis and Suppresses Tumour Growth through Activation of p53 in Endothelial Cells

Fujun Dai; Yihua Chen; Yajuan Song; Li Huang; Dong Zhai; Yanmin Dong; Li Lai; Tao Zhang; Dali Li; Xiufeng Pang; Mingyao Liu; Zhengfang Yi

doi:10.1371/journal.pone.0052162

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Open Access

Peer-reviewed

Research Article

A Natural Small Molecule Harmine Inhibits Angiogenesis and Suppresses Tumour Growth through Activation of p53 in Endothelial Cells

Fujun Dai,

Affiliation Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China
⨯
Yihua Chen ,

* E-mail: yizhengfang@gmail.com (ZY); ibms.ecnu@gmail.com (ML); yhchen79@gmail.com (YC)

Affiliation Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China
⨯
Yajuan Song,

Affiliation Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China
⨯
Li Huang,

Affiliation Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China
⨯
Dong Zhai,

Affiliation Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China
⨯
Yanmin Dong,

Affiliation Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China
⨯
Li Lai,

Affiliation Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China
⨯
Tao Zhang,

Affiliation Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China
⨯
Dali Li,

Affiliation Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China
⨯
Xiufeng Pang,

Affiliation Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China
⨯
Mingyao Liu ,

* E-mail: yizhengfang@gmail.com (ZY); ibms.ecnu@gmail.com (ML); yhchen79@gmail.com (YC)

Affiliations Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China, Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology and Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas, United States of America
⨯
Zhengfang Yi

* E-mail: yizhengfang@gmail.com (ZY); ibms.ecnu@gmail.com (ML); yhchen79@gmail.com (YC)

Affiliation Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China
⨯

A Natural Small Molecule Harmine Inhibits Angiogenesis and Suppresses Tumour Growth through Activation of p53 in Endothelial Cells

Fujun Dai,
Yihua Chen,
Yajuan Song,
Li Huang,
Dong Zhai,
Yanmin Dong,
Li Lai,
Tao Zhang,
Dali Li,
Xiufeng Pang

Published: December 27, 2012
https://doi.org/10.1371/journal.pone.0052162

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Angiogenesis
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Lung and intrathoracic tumors
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Endothelial cells
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Apoptosis
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Cyclins
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Small interfering RNA
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