Targeting 3-Phosphoinoside-Dependent Kinase-1 to Inhibit Insulin-Like Growth Factor-I Induced AKT and p70 S6 Kinase Activation in Breast Cancer Cells

Open Access

Peer-reviewed

Research Article

Sangita M. Baxi,

Affiliation Oncology Research, Pfizer Worldwide Research and Development, San Diego, California, United States of America
⨯
Wei Tan,

Affiliation Oncology Research, Pfizer Worldwide Research and Development, San Diego, California, United States of America
⨯
Sean T. Murphy,

Affiliation Medicinal Chemistry, Pfizer Worldwide Research and Development, San Diego, California, United States of America
⨯
Tod Smeal,

Affiliation Oncology Research, Pfizer Worldwide Research and Development, San Diego, California, United States of America
⨯
Min-Jean Yin

* E-mail: min-jean.yin@pfizer.com

Affiliation Oncology Research, Pfizer Worldwide Research and Development, San Diego, California, United States of America
⨯

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Breast cancer
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Cell proliferation
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Phosphorylation
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Cancer treatment
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Cell cycle and cell division
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Signal inhibition
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Insulin
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Cell transformation
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