Isolation and Characterisation of a Human-Like Antibody Fragment (scFv) That Inactivates VEEV In Vitro and In Vivo

Torsten Rülker; Luzie Voß; Philippe Thullier; Lyn M. O' Brien; Thibaut Pelat; Stuart D. Perkins; Claudia Langermann; Thomas Schirrmann; Stefan Dübel; Hans-Jürgen Marschall; Michael Hust; Birgit Hülseweh

doi:10.1371/journal.pone.0037242

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Peer-reviewed

Research Article

Isolation and Characterisation of a Human-Like Antibody Fragment (scFv) That Inactivates VEEV In Vitro and In Vivo

Torsten Rülker ,

Contributed equally to this work with: Torsten Rülker, Luzie Voß

Affiliation Technische Universität Braunschweig, Institut für Biochemie und Biotechnologie, Braunschweig, Germany
⨯
Luzie Voß ,

Contributed equally to this work with: Torsten Rülker, Luzie Voß

Affiliation Wehrwissenschaftliches Institut für Schutztechnologien (WIS) – ABC-Schutz, Munster, Germany
⨯
Philippe Thullier,

Affiliation Centre de Recherche du Service de Santé des Armées (CRSSA-IRBA), La Tronche, France
⨯
Lyn M. O' Brien,

Affiliation Defence Science and Technology Laboratory, Biomedical Sciences Department, Porton Down, Salisbury, Wiltshire, United Kingdom
⨯
Thibaut Pelat,

Affiliation Centre de Recherche du Service de Santé des Armées (CRSSA-IRBA), La Tronche, France
⨯
Stuart D. Perkins,

Affiliation Defence Science and Technology Laboratory, Biomedical Sciences Department, Porton Down, Salisbury, Wiltshire, United Kingdom
⨯
Claudia Langermann,

Affiliation Wehrwissenschaftliches Institut für Schutztechnologien (WIS) – ABC-Schutz, Munster, Germany
⨯
Thomas Schirrmann,

Affiliation Technische Universität Braunschweig, Institut für Biochemie und Biotechnologie, Braunschweig, Germany
⨯
Stefan Dübel,

Affiliation Technische Universität Braunschweig, Institut für Biochemie und Biotechnologie, Braunschweig, Germany
⨯
Hans-Jürgen Marschall,

Affiliation Wehrwissenschaftliches Institut für Schutztechnologien (WIS) – ABC-Schutz, Munster, Germany
⨯
Michael Hust ,

¶These authors also contributed equally to this work.

Affiliation Technische Universität Braunschweig, Institut für Biochemie und Biotechnologie, Braunschweig, Germany
⨯
Birgit Hülseweh

* E-mail: birgithuelseweh@bwb.org

¶These authors also contributed equally to this work.

Affiliation Wehrwissenschaftliches Institut für Schutztechnologien (WIS) – ABC-Schutz, Munster, Germany
⨯

Isolation and Characterisation of a Human-Like Antibody Fragment (scFv) That Inactivates VEEV In Vitro and In Vivo

Torsten Rülker,
Luzie Voß,
Philippe Thullier,
Lyn M. O' Brien,
Thibaut Pelat,
Stuart D. Perkins,
Claudia Langermann,
Thomas Schirrmann,
Stefan Dübel,
Hans-Jürgen Marschall

Published: May 30, 2012
https://doi.org/10.1371/journal.pone.0037242

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