AMG 837: A Novel GPR40/FFA1 Agonist that Enhances Insulin Secretion and Lowers Glucose Levels in Rodents

Daniel C.-H. Lin; Jane Zhang; Run Zhuang; Frank Li; Kathy Nguyen; Michael Chen; Thanhvien Tran; Edwin Lopez; Jenny Ying Lin Lu; Xiaoyan Nina Li; Liang Tang; George R. Tonn; Gayathri Swaminath; Jeff D. Reagan; Jin-Long Chen; Hui Tian; Yi-Jyun Lin; Jonathan B. Houze; Jian Luo

doi:10.1371/journal.pone.0027270

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Open Access

Peer-reviewed

Research Article

AMG 837: A Novel GPR40/FFA1 Agonist that Enhances Insulin Secretion and Lowers Glucose Levels in Rodents

Daniel C.-H. Lin ,

* E-mail: dclin@amgen.com

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America
⨯
Jane Zhang,

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America
⨯
Run Zhuang,

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America
⨯
Frank Li,

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America
⨯
Kathy Nguyen,

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America
⨯
Michael Chen,

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America
⨯
Thanhvien Tran,

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America
⨯
Edwin Lopez,

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America
⨯
Jenny Ying Lin Lu,

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America
⨯
Xiaoyan Nina Li,

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America
⨯
Liang Tang,

Affiliation Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California, United States America
⨯
George R. Tonn,

Affiliation Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California, United States America
⨯
Gayathri Swaminath,

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America
⨯
Jeff D. Reagan,

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America
⨯
Jin-Long Chen,

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America
⨯
Hui Tian,

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America
⨯
Yi-Jyun Lin,

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America
⨯
Jonathan B. Houze,

Affiliation Chemistry Research and Discovery, Amgen Inc., South San Francisco, California, United States America
⨯
[ ... ],
Jian Luo

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America
⨯
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AMG 837: A Novel GPR40/FFA1 Agonist that Enhances Insulin Secretion and Lowers Glucose Levels in Rodents

Daniel C.-H. Lin,
Jane Zhang,
Run Zhuang,
Frank Li,
Kathy Nguyen,
Michael Chen,
Thanhvien Tran,
Edwin Lopez,
Jenny Ying Lin Lu,
Xiaoyan Nina Li

Published: November 8, 2011
https://doi.org/10.1371/journal.pone.0027270

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