About the Authors

Daniel C.-H. Lin

dclin@amgen.com

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Jane Zhang

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Run Zhuang

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Frank Li

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Kathy Nguyen

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Michael Chen

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Thanhvien Tran

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Edwin Lopez

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Jenny Ying Lin Lu

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Xiaoyan Nina Li

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Liang Tang

Affiliation Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California, United States America

George R. Tonn

Affiliation Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California, United States America

Gayathri Swaminath

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Jeff D. Reagan

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Jin-Long Chen

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Hui Tian

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Yi-Jyun Lin

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Jonathan B. Houze

Affiliation Chemistry Research and Discovery, Amgen Inc., South San Francisco, California, United States America

Jian Luo

Affiliation Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America

Competing Interests

All authors were employed by and shareholders in Amgen during the study period. Patents filed or issued: U.S. Patent No. 7,649,110, U.S. Patent No. 7,816,367 and WO 2005/086661. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DCHL GS JDR JLC HT YJL JBH JL. Performed the experiments: DCHL JZ RZ FL KN MC TT EL JYLL XNL LT JBH. Analyzed the data: DCHL JDR GS GRT YJL JL XNL. Contributed reagents/materials/analysis tools: JBH. Wrote the paper: DCHL.