KAP Degradation by Calpain Is Associated with CK2 Phosphorylation and Provides a Novel Mechanism for Cyclosporine A-Induced Proximal Tubule Injury

Olga Tornavaca; Eduard Sarró; Gloria Pascual; Beatriz Bardaji; M. Angeles Montero; M. Teresa Salcedo; Maria Plana; Joan López-Hellin; Emilio Itarte; Anna Meseguer

doi:10.1371/journal.pone.0025746

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Peer-reviewed

Research Article

KAP Degradation by Calpain Is Associated with CK2 Phosphorylation and Provides a Novel Mechanism for Cyclosporine A-Induced Proximal Tubule Injury

Olga Tornavaca ,

Contributed equally to this work with: Olga Tornavaca, Eduard Sarró

Affiliation Fisiopatologia Renal, Centre d'Investigacions en Bioquímica i Biologia Molecular (CIBBIM), Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron, Barcelona, Spain
⨯
Eduard Sarró ,

Contributed equally to this work with: Olga Tornavaca, Eduard Sarró

Affiliations Fisiopatologia Renal, Centre d'Investigacions en Bioquímica i Biologia Molecular (CIBBIM), Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron, Barcelona, Spain, Unitat de Bioquímica de Biociències, Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Spain
⨯
Gloria Pascual,

Affiliation Fisiopatologia Renal, Centre d'Investigacions en Bioquímica i Biologia Molecular (CIBBIM), Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron, Barcelona, Spain
⨯
Beatriz Bardaji,

Affiliation Fisiopatologia Renal, Centre d'Investigacions en Bioquímica i Biologia Molecular (CIBBIM), Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron, Barcelona, Spain
⨯
M. Angeles Montero,

Affiliation Department of Pathology, Vall d'Hebron University Hospital, Barcelona, Spain
⨯
M. Teresa Salcedo,

Affiliation Department of Pathology, Vall d'Hebron University Hospital, Barcelona, Spain
⨯
Maria Plana,

Affiliation Unitat de Bioquímica de Biociències, Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Spain
⨯
Joan López-Hellin,

Affiliation Fisiopatologia Renal, Centre d'Investigacions en Bioquímica i Biologia Molecular (CIBBIM), Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron, Barcelona, Spain
⨯
Emilio Itarte,

Affiliation Unitat de Bioquímica de Biociències, Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Spain
⨯
Anna Meseguer

* E-mail: ameseguer@ir.vhebron.net

Affiliations Fisiopatologia Renal, Centre d'Investigacions en Bioquímica i Biologia Molecular (CIBBIM), Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron, Barcelona, Spain, Unitat de Bioquímica de Medicina, Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Spain
⨯

KAP Degradation by Calpain Is Associated with CK2 Phosphorylation and Provides a Novel Mechanism for Cyclosporine A-Induced Proximal Tubule Injury

Olga Tornavaca,
Eduard Sarró,
Gloria Pascual,
Beatriz Bardaji,
M. Angeles Montero,
M. Teresa Salcedo,
Maria Plana,
Joan López-Hellin,
Emilio Itarte,
Anna Meseguer

Published: September 28, 2011
https://doi.org/10.1371/journal.pone.0025746

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Phosphorylation
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Kidneys
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Transfection
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Calpain inhibitors
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