A Hypomethylating Variant of MTHFR, 677C>T, Blunts the Neural Response to Errors in Patients with Schizophrenia and Healthy Individuals

Joshua L. Roffman; Adam Z. Nitenson; Yigal Agam; Marlisa Isom; Jesse S. Friedman; Kara A. Dyckman; David G. Brohawn; Jordan W. Smoller; Donald C. Goff; Dara S. Manoach

doi:10.1371/journal.pone.0025253

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Peer-reviewed

Research Article

A Hypomethylating Variant of MTHFR, 677C>T, Blunts the Neural Response to Errors in Patients with Schizophrenia and Healthy Individuals

Joshua L. Roffman ,

* E-mail: jroffman@partners.org

Affiliation Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯
Adam Z. Nitenson,

Affiliation Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯
Yigal Agam,

Affiliation Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯
Marlisa Isom,

Affiliation Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯
Jesse S. Friedman †,

† Deceased.

Affiliation Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯
Kara A. Dyckman,

Affiliation Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯
David G. Brohawn,

Affiliation Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯
Jordan W. Smoller,

Affiliation Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯
Donald C. Goff,

Affiliation Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯
Dara S. Manoach

Affiliation Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯

A Hypomethylating Variant of MTHFR, 677C>T, Blunts the Neural Response to Errors in Patients with Schizophrenia and Healthy Individuals

Joshua L. Roffman,
Adam Z. Nitenson,
Yigal Agam,
Marlisa Isom,
Jesse S. Friedman,
Kara A. Dyckman,
David G. Brohawn,
Jordan W. Smoller,
Donald C. Goff,
Dara S. Manoach

Published: September 28, 2011
https://doi.org/10.1371/journal.pone.0025253

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