Novel Peptides Based on HIV-1 gp120 Sequence with Homology to Chemokines Inhibit HIV Infection in Cell Culture

Oleg Chertov; Ning Zhang; Xin Chen; Joost J. Oppenheim; Jacek Lubkowski; Connor McGrath; Raymond C. Sowder II; Bruce J. Crise; Anatoli Malyguine; Michele A. Kutzler; Amber D. Steele; Earl E. Henderson; Thomas J. Rogers

doi:10.1371/journal.pone.0014474

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Open Access

Peer-reviewed

Research Article

Novel Peptides Based on HIV-1 gp120 Sequence with Homology to Chemokines Inhibit HIV Infection in Cell Culture

Oleg Chertov,

Affiliation Protein Chemistry Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland, United States of America
⨯
Ning Zhang,

Affiliation Laboratory of Molecular Immunoregulation, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
⨯
Xin Chen,

Affiliation Laboratory of Molecular Immunoregulation, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
⨯
Joost J. Oppenheim,

Affiliation Laboratory of Molecular Immunoregulation, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
⨯
Jacek Lubkowski,

Affiliation Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
⨯
Connor McGrath,

Affiliation Target Structure-Based Drug Discovery Group, Frederick, Maryland, United States of America
⨯
Raymond C. Sowder II,

Affiliation AIDS and Cancer Virus Program, SAIC-Frederick, Inc., Frederick, Maryland, United States of America
⨯
Bruce J. Crise,

Affiliation AIDS and Cancer Virus Program, SAIC-Frederick, Inc., Frederick, Maryland, United States of America
⨯
Anatoli Malyguine,

Affiliation Clinical Services Program, SAIC-Frederick, Inc., Frederick, Maryland, United States of America
⨯
Michele A. Kutzler,

Affiliation Department of Pharmacology, Fels Institute for Cancer Research and Molecular Biology, Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Amber D. Steele,

Affiliation Department of Pharmacology, Fels Institute for Cancer Research and Molecular Biology, Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Earl E. Henderson,

Affiliation Department of Pharmacology, Fels Institute for Cancer Research and Molecular Biology, Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Thomas J. Rogers

* E-mail: rogerst@temple.edu

Affiliation Department of Pharmacology, Fels Institute for Cancer Research and Molecular Biology, Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯

Novel Peptides Based on HIV-1 gp120 Sequence with Homology to Chemokines Inhibit HIV Infection in Cell Culture

Oleg Chertov,
Ning Zhang,
Xin Chen,
Joost J. Oppenheim,
Jacek Lubkowski,
Connor McGrath,
Raymond C. Sowder II,
Bruce J. Crise,
Anatoli Malyguine,
Michele A. Kutzler

Published: January 11, 2011
https://doi.org/10.1371/journal.pone.0014474

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Chemokines
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HIV-1
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Cell binding
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Protein sequencing
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Antibodies
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Coreceptors
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DNA isolation
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