Phenocopy – A Strategy to Qualify Chemical Compounds during Hit-to-Lead and/or Lead Optimization

Patrick Baum; Ramona Schmid; Carina Ittrich; Werner Rust; Katrin Fundel-Clemens; Susanne Siewert; Martin Baur; Lisa Mara; Lore Gruenbaum; Armin Heckel; Roland Eils; Roland E. Kontermann; Gerald J. Roth; Florian Gantner; Andreas Schnapp; John E. Park; Andreas Weith; Karsten Quast; Detlev Mennerich

doi:10.1371/journal.pone.0014272

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Open Access

Peer-reviewed

Research Article

Phenocopy – A Strategy to Qualify Chemical Compounds during Hit-to-Lead and/or Lead Optimization

Patrick Baum ,

Contributed equally to this work with: Patrick Baum, Ramona Schmid

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Ramona Schmid ,

Contributed equally to this work with: Patrick Baum, Ramona Schmid

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Carina Ittrich,

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Werner Rust,

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Katrin Fundel-Clemens,

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Susanne Siewert,

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Martin Baur,

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Lisa Mara,

Affiliation Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America
⨯
Lore Gruenbaum,

Affiliation Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America
⨯
Armin Heckel,

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Roland Eils,

Affiliation Institute of Pharmacy and Molecular Biotechnology/BIOQUANT, University of Heidelberg, Heidelberg, Germany
⨯
Roland E. Kontermann,

Affiliation Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany
⨯
Gerald J. Roth,

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Florian Gantner,

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Andreas Schnapp,

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
John E. Park,

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Andreas Weith,

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
Karsten Quast,

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
⨯
[ ... ],
Detlev Mennerich

* E-mail: detlev.mennerich@boehringer-ingelheim.com

Affiliations Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America
⨯
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Phenocopy – A Strategy to Qualify Chemical Compounds during Hit-to-Lead and/or Lead Optimization

Patrick Baum,
Ramona Schmid,
Carina Ittrich,
Werner Rust,
Katrin Fundel-Clemens,
Susanne Siewert,
Martin Baur,
Lisa Mara,
Lore Gruenbaum,
Armin Heckel

Published: December 10, 2010
https://doi.org/10.1371/journal.pone.0014272

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