About the Authors

Patrick Baum

Contributed equally to this work with: Patrick Baum, Ramona Schmid

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

Ramona Schmid

Contributed equally to this work with: Patrick Baum, Ramona Schmid

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

Carina Ittrich

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

Werner Rust

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

Katrin Fundel-Clemens

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

Susanne Siewert

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

Martin Baur

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

Lisa Mara

Affiliation Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America

Lore Gruenbaum

Affiliation Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America

Armin Heckel

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

Roland Eils

Affiliation Institute of Pharmacy and Molecular Biotechnology/BIOQUANT, University of Heidelberg, Heidelberg, Germany

Roland E. Kontermann

Affiliation Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany

Gerald J. Roth

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

Florian Gantner

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

Andreas Schnapp

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

John E. Park

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

Andreas Weith

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

Karsten Quast

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

Detlev Mennerich

detlev.mennerich@boehringer-ingelheim.com

Affiliations Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, United States of America

Competing Interests

PB, RS, CI, WR, KFC, SS, AH, GJR, FG, AS, JEP, AW and KQ are employees of Boehringer Ingelheim Pharma GmbH and Co. KG DM, LM and LG are employees of Boehringer Ingelheim Pharmaceuticals Inc. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PB RS CI WR RK FG JEP AW KQ DM. Performed the experiments: PB WR SS MB LM DM. Analyzed the data: PB RS CI KFC LM KQ DM. Contributed reagents/materials/analysis tools: PB RS CI WR KFC LG AH RE GJR AS JEP KQ DM. Wrote the paper: PB RS FG AS DM.