Promoter-Wide Hypermethylation of the Ribosomal RNA Gene Promoter in the Suicide Brain

Patrick O. McGowan; Aya Sasaki; Tony C. T. Huang; Alexander Unterberger; Matthew Suderman; Carl Ernst; Michael J. Meaney; Gustavo Turecki; Moshe Szyf

doi:10.1371/journal.pone.0002085

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Open Access

Peer-reviewed

Research Article

Promoter-Wide Hypermethylation of the Ribosomal RNA Gene Promoter in the Suicide Brain

Patrick O. McGowan,

Affiliations Department of Psychiatry, Douglas Mental Health University Institute, Montreal, Quebec, Canada, Department of Neurology and Neurosurgery, McGill Program for the Study of Behaviour, Genes and Environment, McGill University, Montreal, Quebec, Canada, Sackler Program for Epigenetics & Psychobiology, McGill University, Montreal, Quebec, Canada
⨯
Aya Sasaki,

Affiliations Department of Psychiatry, Douglas Mental Health University Institute, Montreal, Quebec, Canada, Department of Neurology and Neurosurgery, McGill Program for the Study of Behaviour, Genes and Environment, McGill University, Montreal, Quebec, Canada, Sackler Program for Epigenetics & Psychobiology, McGill University, Montreal, Quebec, Canada
⨯
Tony C. T. Huang,

Affiliations Sackler Program for Epigenetics & Psychobiology, McGill University, Montreal, Quebec, Canada, Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
⨯
Alexander Unterberger,

Affiliations Sackler Program for Epigenetics & Psychobiology, McGill University, Montreal, Quebec, Canada, Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
⨯
Matthew Suderman,

Affiliations Sackler Program for Epigenetics & Psychobiology, McGill University, Montreal, Quebec, Canada, McGill Centre for Bioinformatics, McGill University, Montreal, Quebec, Canada
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Carl Ernst,

Affiliations Department of Psychiatry, Douglas Mental Health University Institute, Montreal, Quebec, Canada, McGill Group for Suicide Studies, Douglas Mental Health University Institute, Montreal, Quebec, Canada
⨯
Michael J. Meaney,

Affiliations Department of Psychiatry, Douglas Mental Health University Institute, Montreal, Quebec, Canada, Department of Neurology and Neurosurgery, McGill Program for the Study of Behaviour, Genes and Environment, McGill University, Montreal, Quebec, Canada, Sackler Program for Epigenetics & Psychobiology, McGill University, Montreal, Quebec, Canada
⨯
Gustavo Turecki ,

* E-mail: gustvao.turecki@mcgill.ca (GT); moshe.szyf@mcgill.ca (MS)

Affiliations Department of Psychiatry, Douglas Mental Health University Institute, Montreal, Quebec, Canada, McGill Group for Suicide Studies, Douglas Mental Health University Institute, Montreal, Quebec, Canada
⨯
Moshe Szyf

* E-mail: gustvao.turecki@mcgill.ca (GT); moshe.szyf@mcgill.ca (MS)

Affiliations Sackler Program for Epigenetics & Psychobiology, McGill University, Montreal, Quebec, Canada, Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
⨯

Promoter-Wide Hypermethylation of the Ribosomal RNA Gene Promoter in the Suicide Brain

Patrick O. McGowan,
Aya Sasaki,
Tony C. T. Huang,
Alexander Unterberger,
Matthew Suderman,
Carl Ernst,
Michael J. Meaney,
Gustavo Turecki,
Moshe Szyf

Published: May 7, 2008
https://doi.org/10.1371/journal.pone.0002085

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DNA methylation
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Ribosomal RNA
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Suicide
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Cloning
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Hippocampus
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Gene expression
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Child abuse
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Epigenetics
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