Nonvirally Modified Autologous Primary Hepatocytes Correct Diabetes and Prevent Target Organ Injury in a Large Preclinical Model

Nelson K. F. Chen; Jen San Wong; Irene H. C. Kee; Siang Hui Lai; Choon Hua Thng; Wai Har Ng; Robert T. H. Ng; Soo Yong Tan; Shu Yen Lee; Mark E. H. Tan; Jaichandran Sivalingam; Pierce K. H. Chow; Oi Lian Kon

doi:10.1371/journal.pone.0001734

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Open Access

Peer-reviewed

Research Article

Nonvirally Modified Autologous Primary Hepatocytes Correct Diabetes and Prevent Target Organ Injury in a Large Preclinical Model

Nelson K. F. Chen,

Affiliation Division of Medical Sciences, National Cancer Centre, Singapore, Republic of Singapore
⨯
Jen San Wong,

Affiliations Division of Medical Sciences, National Cancer Centre, Singapore, Republic of Singapore, Department of General Surgery, Singapore General Hospital, Singapore, Republic of Singapore
⨯
Irene H. C. Kee,

Affiliation Department of Experimental Surgery, Singapore General Hospital, Singapore, Republic of Singapore
⨯
Siang Hui Lai,

Affiliation Centre for Forensic Medicine, Health Sciences Authority, Singapore, Republic of Singapore
⨯
Choon Hua Thng,

Affiliation Department of Oncologic Imaging, National Cancer Centre, Singapore, Republic of Singapore
⨯
Wai Har Ng,

Affiliation Division of Medical Sciences, National Cancer Centre, Singapore, Republic of Singapore
⨯
Robert T. H. Ng,

Affiliation Department of Experimental Surgery, Singapore General Hospital, Singapore, Republic of Singapore
⨯
Soo Yong Tan,

Affiliation Department of Pathology, Singapore General Hospital, Singapore, Republic of Singapore
⨯
Shu Yen Lee,

Affiliation Singapore National Eye Centre, Singapore, Republic of Singapore
⨯
Mark E. H. Tan,

Affiliation Division of Medical Sciences, National Cancer Centre, Singapore, Republic of Singapore
⨯
Jaichandran Sivalingam,

Affiliation Division of Medical Sciences, National Cancer Centre, Singapore, Republic of Singapore
⨯
Pierce K. H. Chow ,

*To whom correspondence should be addressed. E-mail: gsupc@sgh.com.sg (PC); dmskol@nccs.com.sg (OK)

Affiliations Department of General Surgery, Singapore General Hospital, Singapore, Republic of Singapore, Department of Experimental Surgery, Singapore General Hospital, Singapore, Republic of Singapore
⨯
Oi Lian Kon

*To whom correspondence should be addressed. E-mail: gsupc@sgh.com.sg (PC); dmskol@nccs.com.sg (OK)

Affiliation Division of Medical Sciences, National Cancer Centre, Singapore, Republic of Singapore
⨯

Nonvirally Modified Autologous Primary Hepatocytes Correct Diabetes and Prevent Target Organ Injury in a Large Preclinical Model

Nelson K. F. Chen,
Jen San Wong,
Irene H. C. Kee,
Siang Hui Lai,
Choon Hua Thng,
Wai Har Ng,
Robert T. H. Ng,
Soo Yong Tan,
Shu Yen Lee,
Mark E. H. Tan

Published: March 5, 2008
https://doi.org/10.1371/journal.pone.0001734

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