CD4+CD25+FOXP3+ Regulatory T Cells Suppress Anti-Tumor Immune Responses in Patients with Colorectal Cancer

Sarah L. Clarke; Gareth J. Betts; Andrea Plant; Kate L. Wright; Tariq M. El-Shanawany; Richard Harrop; Jared Torkington; Brian I. Rees; Geraint T. Williams; Awen M. Gallimore; Andrew J. Godkin

doi:10.1371/journal.pone.0000129

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Open Access

Peer-reviewed

Research Article

CD4⁺CD25⁺FOXP3⁺ Regulatory T Cells Suppress Anti-Tumor Immune Responses in Patients with Colorectal Cancer

Sarah L. Clarke ,

Contributed equally to this work with: Sarah L. Clarke, Gareth J. Betts, Awen M. Gallimore, Andrew J. Godkin

*To whom correspondence should be addressed. E-mail: godkinaj@cf.ac.uk

Affiliation Department of Medical Biochemistry and Immunology, Cardiff University, Cardiff, United Kingdom
⨯
Gareth J. Betts ,

Contributed equally to this work with: Sarah L. Clarke, Gareth J. Betts, Awen M. Gallimore, Andrew J. Godkin

Affiliation Department of Medical Biochemistry and Immunology, Cardiff University, Cardiff, United Kingdom
⨯
Andrea Plant,

Affiliation Department of Medical Biochemistry and Immunology, Cardiff University, Cardiff, United Kingdom
⨯
Kate L. Wright,

Affiliation Department of Medical Biochemistry and Immunology, Cardiff University, Cardiff, United Kingdom
⨯
Tariq M. El-Shanawany,

Affiliation Department of Medical Biochemistry and Immunology, Cardiff University, Cardiff, United Kingdom
⨯
Richard Harrop,

Affiliation Oxford Biomedica, Oxford, United Kingdom
⨯
Jared Torkington,

Affiliation Department of Surgery, University Hospital of Wales, Cardiff, United Kingdom
⨯
Brian I. Rees,

Affiliation Department of Surgery, University Hospital of Wales, Cardiff, United Kingdom
⨯
Geraint T. Williams,

Affiliation Department of Pathology, Cardiff University, Cardiff, United Kingdom
⨯
Awen M. Gallimore ,

Contributed equally to this work with: Sarah L. Clarke, Gareth J. Betts, Awen M. Gallimore, Andrew J. Godkin

Affiliation Department of Medical Biochemistry and Immunology, Cardiff University, Cardiff, United Kingdom
⨯
Andrew J. Godkin

Contributed equally to this work with: Sarah L. Clarke, Gareth J. Betts, Awen M. Gallimore, Andrew J. Godkin

Affiliation Department of Medical Biochemistry and Immunology, Cardiff University, Cardiff, United Kingdom
⨯

CD4⁺CD25⁺FOXP3⁺ Regulatory T Cells Suppress Anti-Tumor Immune Responses in Patients with Colorectal Cancer

Sarah L. Clarke,
Gareth J. Betts,
Andrea Plant,
Kate L. Wright,
Tariq M. El-Shanawany,
Richard Harrop,
Jared Torkington,
Brian I. Rees,
Geraint T. Williams,
Awen M. Gallimore

Published: December 27, 2006
https://doi.org/10.1371/journal.pone.0000129

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