The Spatial Association of Gene Expression Evolves from Synchrony to Asynchrony and Stochasticity with Age

Qi Wang; Jianhua Huang; Xinmin Zhang; Bin Wu; Xiaoyu Liu; Ziyin Shen

doi:10.1371/journal.pone.0024076

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Peer-reviewed

Research Article

The Spatial Association of Gene Expression Evolves from Synchrony to Asynchrony and Stochasticity with Age

Qi Wang ,

Contributed equally to this work with: Qi Wang, Jianhua Huang

* E-mail: wtq_flying@hotmail.com(WQ); ziyinshen@126.com (ZS)

Affiliations Huashan Hospital, Fudan University, Shanghai, China, National Engineering Center for Biochip, Shanghai, China
⨯
Jianhua Huang ,

Contributed equally to this work with: Qi Wang, Jianhua Huang

Affiliation Huashan Hospital, Fudan University, Shanghai, China
⨯
Xinmin Zhang,

Affiliation Huashan Hospital, Fudan University, Shanghai, China
⨯
Bin Wu,

Affiliation Huashan Hospital, Fudan University, Shanghai, China
⨯
Xiaoyu Liu,

Affiliation Shanghai Tenth People's Hospital of Tongji University, Shanghai, China
⨯
Ziyin Shen

* E-mail: wtq_flying@hotmail.com(WQ); ziyinshen@126.com (ZS)

Affiliation Huashan Hospital, Fudan University, Shanghai, China
⨯

The Spatial Association of Gene Expression Evolves from Synchrony to Asynchrony and Stochasticity with Age

Qi Wang,
Jianhua Huang,
Xinmin Zhang,
Bin Wu,
Xiaoyu Liu,
Ziyin Shen

Published: September 2, 2011
https://doi.org/10.1371/journal.pone.0024076

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Correction for a observed example in female mice after re-analysis of new AGEMAP data.

Posted by submit2plos on 29 Sep 2011 at 07:33 GMT

For example in mice, a significant number of genes with downregulated expression from 1 to 6 months in muscle (MU_6Mv1M_down) also decreased expression from age 6 to 16 months in heart (HE_16Mv6M_down). However, expression increased in spinal cord (SC_16Mv6M_up) (Figure 3B);
http://plosone.org/article/info:doi/10.1371/journal.pone.0024076#article1.body1.sec2.sec4.p1

For example in mice, a significant number of genes with upregulated expression from 1 to 6 months in muscle (MU_6Mv1M_up) exhibited upregulated expression from age 6 to 16 months in hippocampus (HI_16Mv6M_up), also showed downregulated expression from 16 to 24 months in thymus (TH_24Mv16M_down) (new Figure 3B);

No competing interests declared.

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The Spatial Association of Gene Expression Evolves from Synchrony to Asynchrony and Stochasticity with Age

The Spatial Association of Gene Expression Evolves from Synchrony to Asynchrony and Stochasticity with Age

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Correction for a observed example in female mice after re-analysis of new AGEMAP data.

Posted by submit2plos on 29 Sep 2011 at 07:33 GMT