About the Authors

Qi Wang

Contributed equally to this work with: Qi Wang, Jianhua Huang

wtq_flying@hotmail.com(WQ); ziyinshen@126.com (ZS)

Affiliations Huashan Hospital, Fudan University, Shanghai, China, National Engineering Center for Biochip, Shanghai, China

Jianhua Huang

Contributed equally to this work with: Qi Wang, Jianhua Huang

Affiliation Huashan Hospital, Fudan University, Shanghai, China

Xinmin Zhang

Affiliation Huashan Hospital, Fudan University, Shanghai, China

Bin Wu

Affiliation Huashan Hospital, Fudan University, Shanghai, China

Xiaoyu Liu

Affiliation Shanghai Tenth People's Hospital of Tongji University, Shanghai, China

Ziyin Shen

wtq_flying@hotmail.com(WQ); ziyinshen@126.com (ZS)

Affiliation Huashan Hospital, Fudan University, Shanghai, China

Competing Interests

QW is currently an employee of National Engineering Center for Biochip at Shanghai. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ZS. Performed the experiments: JH XZ BW XL. Analyzed the data: QW. Wrote the paper: QW JH. Designed algorithm and developed software: QW. Conceived the study: QW.