Optimising Cell Aggregate Expansion in a Perfused Hollow Fibre Bioreactor via Mathematical Modelling

Lloyd A. C. Chapman; Rebecca J. Shipley; Jonathan P. Whiteley; Marianne J. Ellis; Helen M. Byrne; Sarah L. Waters

doi:10.1371/journal.pone.0105813

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Peer-reviewed

Research Article

Optimising Cell Aggregate Expansion in a Perfused Hollow Fibre Bioreactor via Mathematical Modelling

Lloyd A. C. Chapman,

Affiliations Mathematical Institute, University of Oxford, Oxford, United Kingdom, Department of Computer Science, University of Oxford, Oxford, United Kingdom
⨯
Rebecca J. Shipley,

Affiliation Department of Mechanical Engineering, UCL, London, United Kingdom
⨯
Jonathan P. Whiteley,

Affiliation Department of Computer Science, University of Oxford, Oxford, United Kingdom
⨯
Marianne J. Ellis,

Affiliation Department of Chemical Engineering, University of Bath, Bath, United Kingdom
⨯
Helen M. Byrne,

Affiliations Mathematical Institute, University of Oxford, Oxford, United Kingdom, Department of Computer Science, University of Oxford, Oxford, United Kingdom
⨯
Sarah L. Waters

* E-mail: waters@maths.ox.ac.uk

Affiliation Mathematical Institute, University of Oxford, Oxford, United Kingdom
⨯

Optimising Cell Aggregate Expansion in a Perfused Hollow Fibre Bioreactor via Mathematical Modelling

Lloyd A. C. Chapman,
Rebecca J. Shipley,
Jonathan P. Whiteley,
Marianne J. Ellis,
Helen M. Byrne,
Sarah L. Waters

Published: August 26, 2014
https://doi.org/10.1371/journal.pone.0105813

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Correction to calculation of maximal oxygen uptake flux on page 6

Posted by Lloyd_Chapman on 04 Dec 2014 at 02:12 GMT

There is a typographical mistake in the calculation of the maximal uptake flux at the bottom of the right-hand column on page 6. The cell volume is given as 1.6 x 10^-5m³, but it should be 1.6 x 10^-15m³.

No competing interests declared.

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Optimising Cell Aggregate Expansion in a Perfused Hollow Fibre Bioreactor via Mathematical Modelling

Optimising Cell Aggregate Expansion in a Perfused Hollow Fibre Bioreactor via Mathematical Modelling

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Correction to calculation of maximal oxygen uptake flux on page 6

Posted by Lloyd_Chapman on 04 Dec 2014 at 02:12 GMT