About the Authors

Mitsuharu Matsumoto

Roles Data curation, Investigation, Writing – original draft

mitsuharu.matsumoto@axcelead.com

Affiliation Department of Integrated Biology, Axcelead Drug Discovery Partners, Inc., Fujisawa, Kanagawa, Japan

Hiroaki Yashiro

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

Affiliation Gastroenterology Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Cambridge, Massachusetts, United States of America

Hitomi Ogino

Roles Investigation

Affiliation Department of Integrated Biology, Axcelead Drug Discovery Partners, Inc., Fujisawa, Kanagawa, Japan

Kazunobu Aoyama

Roles Investigation

Affiliation Department of Drug Disposition & Analysis, Axcelead Drug Discovery Partners, Inc., Fujisawa, Kanagawa, Japan

Tadahiro Nambu

Roles Investigation

Affiliation Department of Nonclinical Safety Research, Axcelead Drug Discovery Partners, Inc., Fujisawa, Kanagawa, Japan

Sayuri Nakamura

Roles Investigation

Affiliation Department of Nonclinical Safety Research, Axcelead Drug Discovery Partners, Inc., Fujisawa, Kanagawa, Japan

Mayumi Nishida

Roles Investigation

Affiliation Department of Integrated Biology, Axcelead Drug Discovery Partners, Inc., Fujisawa, Kanagawa, Japan

Xiaolun Wang

Roles Project administration

Affiliation Gastroenterology Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Cambridge, Massachusetts, United States of America

Derek M. Erion

Roles Project administration, Supervision, Writing – review & editing

Affiliation Gastroenterology Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Cambridge, Massachusetts, United States of America

Manami Kaneko

Roles Data curation, Investigation, Supervision, Writing – review & editing

Affiliation Department of Integrated Biology, Axcelead Drug Discovery Partners, Inc., Fujisawa, Kanagawa, Japan

Competing Interests

There is no competing interest exists. The commercial affiliation between Takeda and Axcelead dose not alter our adherence to PLOS ONE policies on sharing data and materials.