About the Authors

Mengli Zhang

Contributed equally to this work with: Mengli Zhang, Jian Wu

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, and The Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Key Laboratory of Medical Epigenetics and Metabolism, Shanghai Medical College, Fudan University, Shanghai, China

Jian Wu

Contributed equally to this work with: Mengli Zhang, Jian Wu

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China

Renqiang Sun

Roles Data curation, Investigation, Methodology, Resources, Validation

Affiliation Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, and The Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Key Laboratory of Medical Epigenetics and Metabolism, Shanghai Medical College, Fudan University, Shanghai, China

Xiaoting Tao

Roles Data curation, Investigation, Methodology, Resources

Affiliation Department of Thoracic Surgery and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

Xiaoxia Wang

Roles Data curation, Methodology, Software, Visualization

Affiliation Waters corporation Shanghai Science & Technology Co Ltd, Shanghai, China

Qi Kang

Roles Data curation, Investigation, Validation, Visualization

Affiliation Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, and The Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Key Laboratory of Medical Epigenetics and Metabolism, Shanghai Medical College, Fudan University, Shanghai, China

Hui Wang

Roles Data curation, Methodology, Software, Visualization

Affiliation Waters corporation Shanghai Science & Technology Co Ltd, Shanghai, China

Lei Zhang

Roles Data curation, Methodology, Software, Visualization

Affiliation Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, and The Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Key Laboratory of Medical Epigenetics and Metabolism, Shanghai Medical College, Fudan University, Shanghai, China

Peng Liu

Roles Data curation, Methodology, Software, Visualization

Affiliation Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, and The Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Key Laboratory of Medical Epigenetics and Metabolism, Shanghai Medical College, Fudan University, Shanghai, China

Jinye Zhang

Roles Data curation, Methodology, Validation

Affiliation Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, and The Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Key Laboratory of Medical Epigenetics and Metabolism, Shanghai Medical College, Fudan University, Shanghai, China

Yukun Xia

Roles Data curation, Resources

Affiliation Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, and The Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Key Laboratory of Medical Epigenetics and Metabolism, Shanghai Medical College, Fudan University, Shanghai, China

Yuzheng Zhao

Roles Resources

Affiliation School of Pharmacy, East China University of Science and Technology, Shanghai, China

Yi Yang

Roles Resources

Affiliation School of Pharmacy, East China University of Science and Technology, Shanghai, China

Yue Xiong

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

Affiliations Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, and The Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Key Laboratory of Medical Epigenetics and Metabolism, Shanghai Medical College, Fudan University, Shanghai, China, Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Kun-Liang Guan

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

kuguan@ucsd.edu (KLG); zou.yunzeng@zs-hospital.sh.cn (YZZ); yedan@fudan.edu.cn (DY)

Affiliations Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, and The Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Key Laboratory of Medical Epigenetics and Metabolism, Shanghai Medical College, Fudan University, Shanghai, China, Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, California, United States

Yunzeng Zou

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

kuguan@ucsd.edu (KLG); zou.yunzeng@zs-hospital.sh.cn (YZZ); yedan@fudan.edu.cn (DY)

Affiliation Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China

Dan Ye

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

kuguan@ucsd.edu (KLG); zou.yunzeng@zs-hospital.sh.cn (YZZ); yedan@fudan.edu.cn (DY)

Affiliations Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, and The Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Key Laboratory of Medical Epigenetics and Metabolism, Shanghai Medical College, Fudan University, Shanghai, China, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China

Competing Interests

XXW and HW are employed by Waters corporation Shanghai Science & Technology Co Ltd (http://www.waters.com/waters/home.htm?locale=zh_CN). There are no patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.