About the Authors

Agnes Gardet

dania.rabah@biogen.com (DR); agnes.gardet@biogen.com (AG)

Affiliation Biogen, Cambridge, Massachusetts, United States of America

Wei C. Chou

Affiliation Biogen, Cambridge, Massachusetts, United States of America

Taylor L. Reynolds

Affiliation Biogen, Cambridge, Massachusetts, United States of America

Diana B. Velez

Affiliation Biogen, Cambridge, Massachusetts, United States of America

Kai Fu

Affiliation Biogen, Cambridge, Massachusetts, United States of America

Julia M. Czerkowicz

Affiliation Biogen, Cambridge, Massachusetts, United States of America

Jeffrey Bajko

Affiliation Biogen, Cambridge, Massachusetts, United States of America

Ann M. Ranger

Affiliation Biogen, Cambridge, Massachusetts, United States of America

Normand Allaire

Affiliation Biogen, Cambridge, Massachusetts, United States of America

Hannah M. Kerns

Affiliation Biogen, Cambridge, Massachusetts, United States of America

Sarah Ryan

Affiliation Biogen, Cambridge, Massachusetts, United States of America

Holly M. Legault

Affiliation Biogen, Cambridge, Massachusetts, United States of America

Robert W. Dunstan

Affiliation Biogen, Cambridge, Massachusetts, United States of America

Robert Lafyatis

Affiliation Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, United States of America

Matvey Lukashev

Affiliation Biogen, Cambridge, Massachusetts, United States of America

Joanne L. Viney

Affiliation Biogen, Cambridge, Massachusetts, United States of America

Jeffrey L. Browning

Affiliation Boston University School of Medicine, Department of Microbiology, Boston, United States of America

Dania Rabah

dania.rabah@biogen.com (DR); agnes.gardet@biogen.com (AG)

Affiliation Biogen, Cambridge, Massachusetts, United States of America

Competing Interests

AG, WCC, TLR, DBV, KF, JMC, JB, AMR, NA, HMK, SR, HML, RWD, ML, JLV, JLB and DR were employees of Biogen at the time of the study. RL receives grant support from Shire, Elpidera, Inception, Regeneron, Prism, Genentech, Biogen, Pfizer and Bristol Meyers Squibb and consulting fees from Merck and Momenta. The authors confirm that the authors’ affiliations to companies does not alter their adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: AG JLB DR BL. Formal analysis: AG WCC TLR DVB KF JMC ML DR. Investigation: WCC DBV KF JMC JB HMK HML. Methodology: AG WCC TLR DBV KF JMC JB AMR NA HMK SR HML RWD DR. Project administration: DR. Supervision: AG JV DR. Visualization: AG WCC TLR DR. Writing – original draft: AG DR. Writing – review & editing: AG TLR RL JV JLB DR.