About the Authors

Daryl L. Richie

Affiliation Novartis Institutes for BioMedical Research, Emeryville, CA, United States of America

Kenneth T. Takeoka

Affiliation Novartis Institutes for BioMedical Research, Emeryville, CA, United States of America

Jade Bojkovic

Affiliation Novartis Institutes for BioMedical Research, Emeryville, CA, United States of America

Louis E. Metzger IV

Affiliation Novartis Institutes for BioMedical Research, Emeryville, CA, United States of America

Christopher M. Rath

Affiliation Novartis Institutes for BioMedical Research, Emeryville, CA, United States of America

William S. Sawyer

Affiliation Novartis Institutes for BioMedical Research, Emeryville, CA, United States of America

Jun-Rong Wei

Affiliation Novartis Institutes for BioMedical Research, Emeryville, CA, United States of America

Charles R. Dean

charlesr.dean@novartis.com

Affiliation Novartis Institutes for BioMedical Research, Emeryville, CA, United States of America

Competing Interests

The authors are, at present, or were during the time of their contribution to this manuscript, employed by Novartis. As such, the authors may own stock in Novartis as part of their remuneration for employment. The authors have no competing interests as regards consultancies, patents or products in development or currently marketed. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: DLR CRD. Data curation: JB CMR WSS. Formal analysis: DLR JB CMR WSS. Investigation: DLR KTT CRM JB WSS LEMIV. Methodology: CMR JB LEMIV WSS JRW KTT DLR CRD. Project administration: CRD DLR CMR. Supervision: CRD DLR CMR JRW. Validation: DLR KTT CMR LEMIV JB. Visualization: DLR CMR JB WSS LEMIV JRW. Writing - original draft: DLR CRD. Writing - review & editing: DLR CRD CMR LEMIV JRW.