About the Authors

Alena V. Savonenko

Contributed equally to this work with: Alena V. Savonenko, Tatiana Melnikova

ahorti1@jhmi.edu (AGH); asavone1@jhmi.edu (AS)

Affiliations Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America, Departments of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

Tatiana Melnikova

Contributed equally to this work with: Alena V. Savonenko, Tatiana Melnikova

Affiliation Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

Yuchuan Wang

Affiliation Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

Hayden Ravert

Affiliation Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

Yongjun Gao

Affiliation Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

Jeremy Koppel

Affiliation Litwin-Zucker Research Center, Feinstein Institute for Medical Research, North-Shore Long Island Jewish Health System, Manhasset, NY, United States of America

Deidre Lee

Affiliation Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

Olga Pletnikova

Affiliation Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

Eugenia Cho

Affiliation Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

Nuzhat Sayyida

Affiliation Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

Andrew Hiatt

Affiliation MAPP Biopharmaceutical Inc, San-Diego, CA, United States of America

Juan Troncoso

Affiliations Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America, Departments of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

Peter Davies

Affiliation Litwin-Zucker Research Center, Feinstein Institute for Medical Research, North-Shore Long Island Jewish Health System, Manhasset, NY, United States of America

Robert F. Dannals

Affiliation Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

Martin G. Pomper

Affiliation Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

Andrew G. Horti

ahorti1@jhmi.edu (AGH); asavone1@jhmi.edu (AS)

Affiliation Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

Competing Interests

Co-author Andrew Hiatt is employed by MAPP Biopharmaceutical Inc. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AS TM AGH. Performed the experiments: AS TM YW YG AGH. Analyzed the data: AS AGH. Contributed reagents/materials/analysis tools: OP JT AH JK PD. Wrote the paper: AS TM MGP AGH. Assisted with animal husbandry and PCR analyses: DL EC. Performed the histological analyses: TM NS. Contributed to the study concept and critical revision of the manuscript: HR JT RFD MGP.