About the Authors

Jason S. Cheng

Affiliations Gladstone Institute of Neurological Disease, San Francisco, California, United States of America, Department of Neurological Surgery, University of California San Francisco, San Francisco, California, United States of America

Ryan Craft

Affiliation Gladstone Institute of Neurological Disease, San Francisco, California, United States of America

Gui-Qiu Yu

Affiliation Gladstone Institute of Neurological Disease, San Francisco, California, United States of America

Kaitlyn Ho

Affiliation Gladstone Institute of Neurological Disease, San Francisco, California, United States of America

Xin Wang

Affiliation Gladstone Institute of Neurological Disease, San Francisco, California, United States of America

Geetha Mohan

Affiliation Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America

Sergey Mangnitsky

Affiliation Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America

Ravikumar Ponnusamy

Affiliation Gladstone Institute of Neurological Disease, San Francisco, California, United States of America

Lennart Mucke

lmucke@gladstone.ucsf.edu

Affiliations Gladstone Institute of Neurological Disease, San Francisco, California, United States of America, Department of Neurology, University of California San Francisco, California, United States of America

Competing Interests

LM has received research funding from Bristol-Myers Squibb and has served on the scientific advisory board of iPierian. He is a co-inventor on patent applications/patents relating to tau reduction that are owned by the Gladstone Institutes (U.S. Patent Publication Number 20120198573; U.S. Patent Publication Number 20140065206; and EP Patent No. 2145014), all of which are entitled “Agents that Reduce Neuronal Overexcitation”. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JC GY GM SM RP LM. Performed the experiments: JC RC GY XW KH GM SM. Analyzed the data: JC SM RP LM. Contributed reagents/materials/analysis tools: SM. Wrote the paper: JC LM.