In Silico, Experimental, Mechanistic Model for Extended-Release Felodipine Disposition Exhibiting Complex Absorption and a Highly Variable Food Interaction

Sean H. J. Kim; Andre J. Jackson; C. Anthony Hunt

doi:10.1371/journal.pone.0108392

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Open Access

Peer-reviewed

Research Article

In Silico, Experimental, Mechanistic Model for Extended-Release Felodipine Disposition Exhibiting Complex Absorption and a Highly Variable Food Interaction

Sean H. J. Kim ,

* E-mail: skim@pitt.edu

Affiliation Department of Pharmacy and Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Andre J. Jackson,

Affiliation Office of Clinical Pharmacology, Food and Drug Administration, Silver Spring, Maryland, United States of America
⨯
C. Anthony Hunt

Affiliation Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America
⨯

In Silico, Experimental, Mechanistic Model for Extended-Release Felodipine Disposition Exhibiting Complex Absorption and a Highly Variable Food Interaction

Sean H. J. Kim,
Andre J. Jackson,
C. Anthony Hunt

Published: September 30, 2014
https://doi.org/10.1371/journal.pone.0108392

About the Authors

Sean H. J. Kim

* E-mail: skim@pitt.edu

Affiliation Department of Pharmacy and Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Andre J. Jackson

Affiliation Office of Clinical Pharmacology, Food and Drug Administration, Silver Spring, Maryland, United States of America

C. Anthony Hunt

Affiliation Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SHJK AJJ CAH. Performed the experiments: SHJK AJJ. Analyzed the data: SHJK AJJ CAH. Contributed to the writing of the manuscript: SHJK AJJ CAH.

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Pharmacokinetics
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Agent-based modeling
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Drug-food interactions
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Drug absorption
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Drug interactions
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Food
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Biophysical simulations
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Computer software
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