About the Authors

Miia H. Leskinen

Affiliation Department of Internal Medicine, School of Medicine, University of Tampere, Tampere, Finland

Elina J. Hautaniemi

elina.hautaniemi@uta.fi

Affiliation Department of Internal Medicine, School of Medicine, University of Tampere, Tampere, Finland

Anna M. Tahvanainen

Affiliation Department of Internal Medicine, School of Medicine, University of Tampere, Tampere, Finland

Jenni K. Koskela

Affiliation Department of Internal Medicine, School of Medicine, University of Tampere, Tampere, Finland

Marika Päällysaho

Affiliation Department of Internal Medicine, School of Medicine, University of Tampere, Tampere, Finland

Antti J. Tikkakoski

Affiliation Department of Internal Medicine, School of Medicine, University of Tampere, Tampere, Finland

Mika Kähönen

Affiliations Department of Internal Medicine, School of Medicine, University of Tampere, Tampere, Finland, Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland

Tiit Kööbi

Affiliation Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland

Onni Niemelä

Affiliations Department of Internal Medicine, School of Medicine, University of Tampere, Tampere, Finland, Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital, Seinäjoki, Finland

Jukka Mustonen

Affiliations Department of Internal Medicine, School of Medicine, University of Tampere, Tampere, Finland, Department of Internal Medicine, Tampere University Hospital, Tampere, Finland

Ilkka H. Pörsti

Affiliations Department of Internal Medicine, School of Medicine, University of Tampere, Tampere, Finland, Department of Internal Medicine, Tampere University Hospital, Tampere, Finland

Competing Interests

The funding from the commercial source (Astra Zeneca Plc.) was a relatively small personal research grant to author Miia Leskinen (5000 ). Application to this funding by Astra Zeneca Plc was open nation-wide in Finland for all Ph.D. students doing biomedical research, and the funds were granted on the basis of the present study protocol. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MHL IHP. Performed the experiments: MHL AMT JKK MP IHP. Analyzed the data: MHL EJH AMT AJT IHP. Contributed reagents/materials/analysis tools: AMT JKK MK TK ON JM IHP. Wrote the paper: MHL EJH AMT JM IHP. Ethical approval and registration at ClinicalTrials.gov: MHJ AMT IHP.