Convallatoxin, a Dual Inducer of Autophagy and Apoptosis, Inhibits Angiogenesis In Vitro and In Vivo

Seung Ya Yang; Nam Hee Kim; Yoon Sun Cho; Hukeun Lee; Ho Jeong Kwon

doi:10.1371/journal.pone.0091094

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Open Access

Peer-reviewed

Research Article

Convallatoxin, a Dual Inducer of Autophagy and Apoptosis, Inhibits Angiogenesis In Vitro and In Vivo

Seung Ya Yang,

Affiliation Department of Biotechnology, Translational Research Center for Protein Function Control, College of Life Science & Biotechnology, Yonsei University, Seoul, Korea
⨯
Nam Hee Kim,

Affiliation Department of Biotechnology, Translational Research Center for Protein Function Control, College of Life Science & Biotechnology, Yonsei University, Seoul, Korea
⨯
Yoon Sun Cho,

Affiliation Department of Biotechnology, Translational Research Center for Protein Function Control, College of Life Science & Biotechnology, Yonsei University, Seoul, Korea
⨯
Hukeun Lee,

Affiliation Department of Biotechnology, Translational Research Center for Protein Function Control, College of Life Science & Biotechnology, Yonsei University, Seoul, Korea
⨯
Ho Jeong Kwon

* E-mail: kwonhj@yonsei.ac.kr

Affiliation Department of Biotechnology, Translational Research Center for Protein Function Control, College of Life Science & Biotechnology, Yonsei University, Seoul, Korea
⨯

Convallatoxin, a Dual Inducer of Autophagy and Apoptosis, Inhibits Angiogenesis In Vitro and In Vivo

Seung Ya Yang,
Nam Hee Kim,
Yoon Sun Cho,
Hukeun Lee,
Ho Jeong Kwon

Published: March 24, 2014
https://doi.org/10.1371/journal.pone.0091094

About the Authors

Seung Ya Yang

Affiliation Department of Biotechnology, Translational Research Center for Protein Function Control, College of Life Science & Biotechnology, Yonsei University, Seoul, Korea

Nam Hee Kim

Affiliation Department of Biotechnology, Translational Research Center for Protein Function Control, College of Life Science & Biotechnology, Yonsei University, Seoul, Korea

Yoon Sun Cho

Affiliation Department of Biotechnology, Translational Research Center for Protein Function Control, College of Life Science & Biotechnology, Yonsei University, Seoul, Korea

Hukeun Lee

Affiliation Department of Biotechnology, Translational Research Center for Protein Function Control, College of Life Science & Biotechnology, Yonsei University, Seoul, Korea

Ho Jeong Kwon

* E-mail: kwonhj@yonsei.ac.kr

Affiliation Department of Biotechnology, Translational Research Center for Protein Function Control, College of Life Science & Biotechnology, Yonsei University, Seoul, Korea

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HJK SYY. Performed the experiments: SYY NHK YSC HL. Analyzed the data: HJK SYY NHK YSC HL. Contributed reagents/materials/analysis tools: HJK. Wrote the paper: HJK SYY YSC.

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Apoptosis
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Autophagic cell death
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HeLa cells
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Angiogenesis
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Cancer treatment
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Cancers and neoplasms
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Glycosides
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Small molecules
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