Disruption of Hydrogen Bonds between Major Histocompatibility Complex Class II and the Peptide N-Terminus Is Not Sufficient to Form a Human Leukocyte Antigen-DM Receptive State of Major Histocompatibility Complex Class II

Monika-Sarah E. D. Schulze; Anne-Kathrin Anders; Dhruv K. Sethi; Melissa J. Call

doi:10.1371/journal.pone.0069228

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Peer-reviewed

Research Article

Disruption of Hydrogen Bonds between Major Histocompatibility Complex Class II and the Peptide N-Terminus Is Not Sufficient to Form a Human Leukocyte Antigen-DM Receptive State of Major Histocompatibility Complex Class II

Monika-Sarah E. D. Schulze,

Affiliation Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Anne-Kathrin Anders,

Affiliations Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Program in Immunology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Dhruv K. Sethi,

Affiliation Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Melissa J. Call

* E-mail: call@wehi.edu.au

Affiliation Structural Biology Division, the Walter and Eliza Hall Institute of Medical Research, the University of Melbourne, Parkville, Victoria, Australia
⨯

Disruption of Hydrogen Bonds between Major Histocompatibility Complex Class II and the Peptide N-Terminus Is Not Sufficient to Form a Human Leukocyte Antigen-DM Receptive State of Major Histocompatibility Complex Class II

Monika-Sarah E. D. Schulze,
Anne-Kathrin Anders,
Dhruv K. Sethi,
Melissa J. Call

Published: July 25, 2013
https://doi.org/10.1371/journal.pone.0069228

About the Authors

Monika-Sarah E. D. Schulze

Affiliation Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Anne-Kathrin Anders

Affiliations Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Program in Immunology, Harvard Medical School, Boston, Massachusetts, United States of America

Dhruv K. Sethi

Affiliation Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Melissa J. Call

* E-mail: call@wehi.edu.au

Affiliation Structural Biology Division, the Walter and Eliza Hall Institute of Medical Research, the University of Melbourne, Parkville, Victoria, Australia

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MJC MSEDS. Performed the experiments: MSEDS DKS. Analyzed the data: MSEDS AKA DKS MJC. Wrote the manuscript: MSEDS MJC.

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Hydrogen bonding
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Crystal structure
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Crystallization
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Molecular structure
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Major histocompatibility complex
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Valine
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Health care
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