Blebbistain, a Myosin II Inhibitor, as a Novel Strategy to Regulate Detrusor Contractility in a Rat Model of Partial Bladder Outlet Obstruction

Xinhua Zhang; Allen Seftel; Michael E. DiSanto

doi:10.1371/journal.pone.0025958

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Peer-reviewed

Research Article

Blebbistain, a Myosin II Inhibitor, as a Novel Strategy to Regulate Detrusor Contractility in a Rat Model of Partial Bladder Outlet Obstruction

Xinhua Zhang,

Affiliations Department of Urology, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Surgery/Division of Urology, Cooper Medical School of Rowan University, Camden, New Jersey, United States of America
⨯
Allen Seftel,

Affiliation Department of Surgery/Division of Urology, Cooper Medical School of Rowan University, Camden, New Jersey, United States of America
⨯
Michael E. DiSanto

* E-mail: disanto-michael@cooperhealth.edu

Affiliations Department of Urology, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Surgery/Division of Urology, Cooper Medical School of Rowan University, Camden, New Jersey, United States of America
⨯

Blebbistain, a Myosin II Inhibitor, as a Novel Strategy to Regulate Detrusor Contractility in a Rat Model of Partial Bladder Outlet Obstruction

Xinhua Zhang,
Allen Seftel,
Michael E. DiSanto

Published: October 7, 2011
https://doi.org/10.1371/journal.pone.0025958

About the Authors

Xinhua Zhang

Affiliations Department of Urology, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Surgery/Division of Urology, Cooper Medical School of Rowan University, Camden, New Jersey, United States of America

Allen Seftel

Affiliation Department of Surgery/Division of Urology, Cooper Medical School of Rowan University, Camden, New Jersey, United States of America

Michael E. DiSanto

* E-mail: disanto-michael@cooperhealth.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MEDS AS XZ. Performed the experiments: XZ MEDS AS. Analyzed the data: XZ MEDS. Contributed reagents/materials/analysis tools: MEDS AS. Wrote the paper: XZ AS MEDS.

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Bladder
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Myosins
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Carbachol
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Muscle contraction
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Polymerase chain reaction
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Smooth muscles
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Alternative splicing
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