The Shedding of CD62L (L-Selectin) Regulates the Acquisition of Lytic Activity in Human Tumor Reactive T Lymphocytes

Shicheng Yang; Fang Liu; Qiong J. Wang; Steven A. Rosenberg; Richard A. Morgan

doi:10.1371/journal.pone.0022560

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Open Access

Peer-reviewed

Research Article

The Shedding of CD62L (L-Selectin) Regulates the Acquisition of Lytic Activity in Human Tumor Reactive T Lymphocytes

Shicheng Yang,

Affiliation Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Fang Liu,

Affiliation Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Qiong J. Wang,

Affiliation Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Steven A. Rosenberg,

Affiliation Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Richard A. Morgan

* E-mail: rmorgan@mail.nih.gov

Affiliation Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

The Shedding of CD62L (L-Selectin) Regulates the Acquisition of Lytic Activity in Human Tumor Reactive T Lymphocytes

Shicheng Yang,
Fang Liu,
Qiong J. Wang,
Steven A. Rosenberg,
Richard A. Morgan

Published: July 28, 2011
https://doi.org/10.1371/journal.pone.0022560

About the Authors

Shicheng Yang

Affiliation Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Fang Liu

Affiliation Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Qiong J. Wang

Affiliation Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Steven A. Rosenberg

Affiliation Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Richard A. Morgan

* E-mail: rmorgan@mail.nih.gov

Affiliation Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SY RAM. Performed the experiments: SY FL QJW. Analyzed the data: SY RAM. Contributed reagents/materials/analysis tools: SY FL QJW. Wrote the paper: SY SAR RAM.

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T cells
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Molting
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Cytotoxic T cells
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Melanoma
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Cancers and neoplasms
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Propidium iodide staining
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Antigen-presenting cells
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Genetic engineering
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