About the Authors

Kirstine J. Belongie

Roles Data curation, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Cardiovascular and Metabolic Disease Research, Janssen Research & Development, Spring House, Pennsylvania, United States of America

Ele Ferrannini

Roles Investigation, Methodology, Resources, Supervision, Validation, Writing – review & editing

Affiliation CNR Institute of Clinical Physiology, Pisa, Italy

Kjell Johnson

Roles Data curation, Formal analysis, Software, Validation, Writing – review & editing

Affiliation Arbor Analytics, Ann Arbor, Michigan, United States of America

Patricia Andrade-Gordon

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation Cardiovascular and Metabolic Disease Research, Janssen Research & Development, Spring House, Pennsylvania, United States of America

Michael K. Hansen

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

‡ These authors are joint senior authors on this work.

Affiliation Cardiovascular and Metabolic Disease Research, Janssen Research & Development, Spring House, Pennsylvania, United States of America

John R. Petrie

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

john.petrie@glasgow.ac.uk

‡ These authors are joint senior authors on this work.

Affiliation Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom

Competing Interests

Dr. Petrie reports personal fees via his employer the University of Glasgow from Novo Nordisk; grants, personal fees and non-financial support from Sanofi Aventis via his employer; non-financial support from Merck (Germany); personal fees from Lilly, non-financial support from Itamar Medical, grants from JDRF (US Charity), grants and personal fees from Quintiles, personal fees from Janssen, personal fees from Boehringer Ingelheim. MKH, PAG, and KJB are employees of Janssen Research & Development, LLC. Dr. Ferrannini reports consulting/speaker fee from Boehringer-Ingelheim/Lilly, MSD, Sanofi, Janssen, and Mitsubishi, and grant support from Boehringer-Ingelheim/Lilly. Funding support was received from Janssen Pharmaceuticals, Novo Nordisk (Europe) and AstraZeneca (Sweden). Kjell Johnson is employed by Arbor Analytics LLC. Kirstine J. Belongie, Patricia Andrade-Gordon, and Michael K. Hansen are employed by Janssen Research & Development LLC. There are no patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.