About the Authors

Donald R. Royall

Contributed equally to this work with: Donald R. Royall, Raymond F. Palmer

royall@uthscsa.edu

Affiliations Department of Psychiatry, the University of Texas Health Science Center, San Antonio, Texas, United States of America, Department of Medicine, the University of Texas Health Science Center, San Antonio, Texas, United States of America, Department of Family and Community Medicine, the University of Texas Health Science Center, San Antonio, Texas, United States of America, South Texas Veterans’ Health System Audie L. Murphy Division Geriatric Research Education and Clinical Care Center, San Antonio, Texas, United States of America

Safa Al-Rubaye

‡ These authors also contributed equally to this work.

Affiliation Department of Psychiatry, the University of Texas Health Science Center, San Antonio, Texas, United States of America

Ram Bishnoi

‡ These authors also contributed equally to this work.

Affiliation Department of Psychiatry, the Medical College of Georgia, Augusta, Georgia, United States of America

Raymond F. Palmer

Contributed equally to this work with: Donald R. Royall, Raymond F. Palmer

Affiliation Department of Family and Community Medicine, the University of Texas Health Science Center, San Antonio, Texas, United States of America

Competing Interests

The authors have disclosed the results of these analyses to the University of Texas Health Science Center at San Antonio (UTHSCSA), which has filed provisional patents 61/603,226: "A Latent Variable Approach to the Identification and/or Diagnosis of Cognitive Disorders", 61/671,858: “A Serum Biomarker Screen for the Diagnosis of Clinical and Pre-clinical Alzheimer’s Disease in Non-Hispanic Populations”, and 62/112,703: “Methods and Approach for Detection and Prediction of Change in Dementia Severity or Clinical Diagnosis over Time” relating to the latent variable δ’s construction and biomarkers. There are no further patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: DRR. Data curation: RFP. Formal analysis: DRR SA RB RFP. Funding acquisition: DRR. Investigation: DRR. Methodology: DRR. Project administration: DRR. Software: RFP DRR. Supervision: DRR. Validation: DRR RFP. Visualization: DRR RFP. Writing – original draft: DRR. Writing – review & editing: DRR SA RB RFP.