About the Authors

Mindy I. Davis

Contributed equally to this work with: Mindy I. Davis, Atsuo T. Sasaki

Affiliation National Institutes of Health Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America

Atsuo T. Sasaki

Contributed equally to this work with: Mindy I. Davis, Atsuo T. Sasaki

Affiliations Beth Israel Deaconess Medical Center, Department of Medicine, Division of Signal Transduction; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Hematology and Oncology, Department of Internal Medicine, Neuroscience Institute: Brain Tumor Center, University of Cincinnati, College of Medicine, Cincinnati, Ohio, United States of America

Min Shen

Affiliation National Institutes of Health Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America

Brooke M. Emerling

Affiliation Beth Israel Deaconess Medical Center, Department of Medicine, Division of Signal Transduction; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Natasha Thorne

Affiliation National Institutes of Health Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America

Sam Michael

Affiliation National Institutes of Health Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America

Rajan Pragani

Affiliation National Institutes of Health Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America

Matthew Boxer

Affiliation National Institutes of Health Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America

Kazutaka Sumita

Affiliation Division of Hematology and Oncology, Department of Internal Medicine, Neuroscience Institute: Brain Tumor Center, University of Cincinnati, College of Medicine, Cincinnati, Ohio, United States of America

Koh Takeuchi

Affiliation Biomedicinal Information Research Center, National Institute of Advanced Industrial Science and Technology, Koto, Tokyo, Japan

Douglas S. Auld

Affiliations National Institutes of Health Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America, Center for Proteomic Chemistry, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Zhuyin Li

Affiliation National Institutes of Health Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America

Lewis C. Cantley

Affiliation Beth Israel Deaconess Medical Center, Department of Medicine, Division of Signal Transduction; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Anton Simeonov

asimeono@mail.nih.gov

Affiliation National Institutes of Health Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MID ATS BME MS NT SM DSA LCC AS KS KT. Performed the experiments: MID ATS BME NT SM KS KT. Analyzed the data: MID ATS MS BME NT SM RP MB DSA ZL LCC AS. Contributed reagents/materials/analysis tools: MID ATS MS BME NT SM RP MB DSA ZL LCC AS KS KT. Wrote the paper: MID ATS MS BME NT SM RP MB DSA ZL LCC AS.