Mitochondrial DNA Damage and Dysfunction, and Oxidative Stress Are Associated with Endoplasmic Reticulum Stress, Protein Degradation and Apoptosis in High Fat Diet-Induced Insulin Resistance Mice

Larysa V. Yuzefovych; Sergiy I. Musiyenko; Glenn L. Wilson; Lyudmila I. Rachek

doi:10.1371/journal.pone.0054059

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Peer-reviewed

Research Article

Mitochondrial DNA Damage and Dysfunction, and Oxidative Stress Are Associated with Endoplasmic Reticulum Stress, Protein Degradation and Apoptosis in High Fat Diet-Induced Insulin Resistance Mice

Larysa V. Yuzefovych,

Affiliation Department of Cell Biology and Neuroscience, University of South Alabama, Mobile, Alabama, United States of America
⨯
Sergiy I. Musiyenko,

Affiliation Department of Cell Biology and Neuroscience, University of South Alabama, Mobile, Alabama, United States of America
⨯
Glenn L. Wilson,

Affiliation Department of Cell Biology and Neuroscience, University of South Alabama, Mobile, Alabama, United States of America
⨯
Lyudmila I. Rachek

* E-mail: lrachek@jaguar1.usouthal.edu

Affiliation Department of Cell Biology and Neuroscience, University of South Alabama, Mobile, Alabama, United States of America
⨯

Mitochondrial DNA Damage and Dysfunction, and Oxidative Stress Are Associated with Endoplasmic Reticulum Stress, Protein Degradation and Apoptosis in High Fat Diet-Induced Insulin Resistance Mice

Larysa V. Yuzefovych,
Sergiy I. Musiyenko,
Glenn L. Wilson,
Lyudmila I. Rachek

Published: January 16, 2013
https://doi.org/10.1371/journal.pone.0054059

About the Authors

Larysa V. Yuzefovych

Affiliation Department of Cell Biology and Neuroscience, University of South Alabama, Mobile, Alabama, United States of America

Sergiy I. Musiyenko

Affiliation Department of Cell Biology and Neuroscience, University of South Alabama, Mobile, Alabama, United States of America

Glenn L. Wilson

Affiliation Department of Cell Biology and Neuroscience, University of South Alabama, Mobile, Alabama, United States of America

Lyudmila I. Rachek

* E-mail: lrachek@jaguar1.usouthal.edu

Affiliation Department of Cell Biology and Neuroscience, University of South Alabama, Mobile, Alabama, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Discussed, edited and revised the manuscript: GLW. Conceived and designed the experiments: LIR. Performed the experiments: LVY SIM LIR. Analyzed the data: LVY LIR. Wrote the paper: LVY LIR.

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Skeletal muscles
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Mitochondria
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Mitochondrial DNA
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Oxidative stress
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DNA damage
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Apoptosis
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Fatty liver
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Obesity
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