Increasing Hippocampal Estrogen Receptor Alpha Levels via Viral Vectors Increases MAP Kinase Activation and Enhances Memory in Aging Rats in the Absence of Ovarian Estrogens

Christine F. Witty; Thomas C. Foster; Susan L. Semple-Rowland; Jill M. Daniel

doi:10.1371/journal.pone.0051385

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Peer-reviewed

Research Article

Increasing Hippocampal Estrogen Receptor Alpha Levels via Viral Vectors Increases MAP Kinase Activation and Enhances Memory in Aging Rats in the Absence of Ovarian Estrogens

Christine F. Witty,

Affiliation Neuroscience Program, Tulane University, New Orleans, Louisiana, United States of America
⨯
Thomas C. Foster,

Affiliation Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America
⨯
Susan L. Semple-Rowland,

Affiliation Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America
⨯
Jill M. Daniel

* E-mail: jmdaniel@tulane.edu

Affiliations Neuroscience Program, Tulane University, New Orleans, Louisiana, United States of America, Department of Psychology, Tulane University, New Orleans, Louisiana, United States of America
⨯

Increasing Hippocampal Estrogen Receptor Alpha Levels via Viral Vectors Increases MAP Kinase Activation and Enhances Memory in Aging Rats in the Absence of Ovarian Estrogens

Christine F. Witty,
Thomas C. Foster,
Susan L. Semple-Rowland,
Jill M. Daniel

Published: December 11, 2012
https://doi.org/10.1371/journal.pone.0051385

About the Authors

Christine F. Witty

Affiliation Neuroscience Program, Tulane University, New Orleans, Louisiana, United States of America

Thomas C. Foster

Affiliation Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America

Susan L. Semple-Rowland

Affiliation Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America

Jill M. Daniel

* E-mail: jmdaniel@tulane.edu

Affiliations Neuroscience Program, Tulane University, New Orleans, Louisiana, United States of America, Department of Psychology, Tulane University, New Orleans, Louisiana, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CFW TCF SLSR JMD. Performed the experiments: CFW TCF SLSR JMD. Analyzed the data: CFW TCF SLSR JMD. Contributed reagents/materials/analysis tools: CFW TCF SLSR JMD. Wrote the paper: CFW TCF SLSR JMD.

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Hippocampus
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Estrogens
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Ovariectomy
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Estradiol
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Rats
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Gene delivery
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Memory
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Protein kinase signaling cascade
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