About the Authors

Inna Y. Gong

Affiliations Department of Physiology & Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada, Division of Clinical Pharmacology, Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

Ute I. Schwarz

Affiliations Department of Physiology & Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada, Division of Clinical Pharmacology, Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

Natalie Crown

Affiliation Division of Clinical Pharmacology, Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

George K. Dresser

Affiliation Division of Clinical Pharmacology, Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

Alejandro Lazo-Langner

Affiliations Division of Hematology, Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada, Department of Epidemiology and Biostatistics, Robarts Clinical Trials, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

GuangYong Zou

Affiliation Department of Epidemiology and Biostatistics, Robarts Clinical Trials, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

Dan M. Roden

Affiliation Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

C. Michael Stein

Affiliation Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Marc Rodger

Affiliation Department of Medicine, University of Ottawa, Ottawa Health Research Institute, Ottawa, Ontario, Canada

Philip S. Wells

Affiliation Department of Medicine, University of Ottawa, Ottawa Health Research Institute, Ottawa, Ontario, Canada

Richard B. Kim

Affiliations Department of Physiology & Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada, Division of Clinical Pharmacology, Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

Rommel G. Tirona

rommel.tirona@schulich.uwo.ca

Affiliations Department of Physiology & Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada, Division of Clinical Pharmacology, Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IYG UIS NC GKD AL-L PSW RBK RGT. Performed the experiments: IYG UIS NC RGT. Analyzed the data: IYG RGT. Wrote the paper: IYG RGT. Critical revision of the paper: IYG UIS NC GKD AL-L GZ DMR CMS MR PSW RBK RGT.