About the Authors

Jonathan M. J. Derry

derry@sagebase.org

Current address: Sage Bionetworks, Seattle, Washington, United States of America

Affiliation Rosetta Inpharmatics LLC, A wholly owned subsidiary of Merck & Co, Seattle, Washington, United States of America

Hua Zhong

Current address: Sage Bionetworks, Seattle, Washington, United States of America

Affiliation Rosetta Inpharmatics LLC, A wholly owned subsidiary of Merck & Co, Seattle, Washington, United States of America

Cliona Molony

Affiliation Rosetta Inpharmatics LLC, A wholly owned subsidiary of Merck & Co, Seattle, Washington, United States of America

Doug MacNeil

Affiliation Basic Research, Merck & Co., Inc., Rahway, New Jersey, United States of America

Debraj Guhathakurta

Current address: Genentech, South San Francisco, California, United States of America

Affiliation Rosetta Inpharmatics LLC, A wholly owned subsidiary of Merck & Co, Seattle, Washington, United States of America

Bin Zhang

Current address: Sage Bionetworks, Seattle, Washington, United States of America

Affiliation Rosetta Inpharmatics LLC, A wholly owned subsidiary of Merck & Co, Seattle, Washington, United States of America

John Mudgett

Affiliation Basic Research, Merck & Co., Inc., Rahway, New Jersey, United States of America

Kersten Small

Affiliation Basic Research, Merck & Co., Inc., Rahway, New Jersey, United States of America

Lahcen El Fertak

Affiliation Institut Clinique de la Souris, Illkirch, France

Alain Guimond

Affiliation Institut Clinique de la Souris, Illkirch, France

Mohammed Selloum

Affiliation Institut Clinique de la Souris, Illkirch, France

Wenqing Zhao

Affiliation Basic Research, Merck & Co., Inc., Rahway, New Jersey, United States of America

Marie France Champy

Affiliation Institut Clinique de la Souris, Illkirch, France

Laurent Monassier

Affiliation Institut Clinique de la Souris, Illkirch, France

Tom Vogt

Affiliation Basic Research, Merck & Co., Inc., Rahway, New Jersey, United States of America

Doris Cully

Affiliation Basic Research, Merck & Co., Inc., Rahway, New Jersey, United States of America

Andrew Kasarskis

Current address: Sage Bionetworks, Seattle, Washington, United States of America

Affiliation Rosetta Inpharmatics LLC, A wholly owned subsidiary of Merck & Co, Seattle, Washington, United States of America

Eric E. Schadt

Current address: Pacific Biosciences, Menlo Park, California, United States of America

Affiliation Rosetta Inpharmatics LLC, A wholly owned subsidiary of Merck & Co, Seattle, Washington, United States of America

Competing Interests

JD, CM, DM, HZ, DG, BZ, JM, KS, TV, DC, AK, ES were all Merck employees at the time this work was carried out. Merck funded the studies detailed in this manuscript but this does not alter the authors' adherence to all PLoS ONE policies on sharing data and materials. Merck has agreed that the microarray data, the genotype data and the phenotypic data associated with this study will be made available in an unrestricted fashion in the public domain including deposition of data to the relevant repositories (e.g. GEO), publication on the PLoS ONE website, and hosted at the Sage Bionetworks public repository for coherent genomic data (http://www.sagebase.org/commons/repository.php).

Author Contributions

Conceived and designed the experiments: CM DG JM TV DC AK EES. Performed the experiments: LEF AG MS MFC LM. Analyzed the data: JMJD HZ CM DM DG BZ JM KS WZ LM DC AK EES. Contributed reagents/materials/analysis tools: WZ. Wrote the paper: JMJD DM.