The tropical bont tick (Amblyomma variegatum) is one of Africa's most beautiful parasites, but also one of its most persistent problems. It frequently bites humans and is a major vector of African tick-bite fever, caused by Rickettsia africae. Alongside its medical impacts, the tropical bont tick commonly infests livestock resulting in a range of livestock disease. Chatanga et al. 2025
Image Credit: Elisha Chatanga and Yuki Ohsugi
Viewpoints
Portable digital microscopy with point-of-care testing for low-cost and efficient prevalence surveys for schistosomiasis control
PLOS Neglected Tropical Diseases: published October 3, 2025 | https://doi.org/10.1371/journal.pntd.0013444
Harnessing traditional healers role in strengthening Africa’s public health response: A case study of Mpox outbreak
PLOS Neglected Tropical Diseases: published October 29, 2025 | https://doi.org/10.1371/journal.pntd.0013655
Reviews
Mycobacterium tuberculosis complex Lineage 1: A neglected cause of tuberculosis
PLOS Neglected Tropical Diseases: published October 9, 2025 | https://doi.org/10.1371/journal.pntd.0013513
Diagnostic heterogeneity in scrub typhus serology: A scoping review of IFA thresholds and regional standardisation needs (2005–2024)
PLOS Neglected Tropical Diseases: published October 22, 2025 | https://doi.org/10.1371/journal.pntd.0013540
Translesion synthesis and microhomology-mediated end-joining repair in trypanosomatids
PLOS Neglected Tropical Diseases: published October 31, 2025 | https://doi.org/10.1371/journal.pntd.0013626
Research Articles
Temporal and spatial profiling of Aedes albopictus immune responses to chikungunya virus infection
PLOS Neglected Tropical Diseases: published October 3, 2025 | https://doi.org/10.1371/journal.pntd.0013588
Severe dengue in adults: Clinical features from the 2022 dengue outbreak at a Vietnamese tertiary hospital
PLOS Neglected Tropical Diseases: published October 3, 2025 | https://doi.org/10.1371/journal.pntd.0013589
Intestinal inflammation induced by heat-labile toxin-producing enterotoxigenic E: Coli infection and impact on immune responses in an experimental human challenge model
PLOS Neglected Tropical Diseases: published October 3, 2025 | https://doi.org/10.1371/journal.pntd.0013025
Clinical and laboratory profiles of Oropouche virus disease from the 2024 outbreak in Manaus, Brazilian Amazon
PLOS Neglected Tropical Diseases: published October 3, 2025 | https://doi.org/10.1371/journal.pntd.0013604
Congenital transmission of Chagas disease by vector circulation zone in Bolivia
PLOS Neglected Tropical Diseases: published October 3, 2025 | https://doi.org/10.1371/journal.pntd.0013591
The effects of mating and blood feeding on the immune defense of female Aedes aegypti mosquitoes
PLOS Neglected Tropical Diseases: published October 3, 2025 | https://doi.org/10.1371/journal.pntd.0013542
The probability of Plasmodium vivax acute illness following primary infection and relapse in Papua New Guinea
PLOS Neglected Tropical Diseases: published October 3, 2025 | https://doi.org/10.1371/journal.pntd.0013567
Evaluating the diagnostic utility of the slide agglutination method for brucellosis in Saudi Arabia: A retrospective study at International Medical Center, Jeddah, Saudi Arabia
PLOS Neglected Tropical Diseases: published October 6, 2025 | https://doi.org/10.1371/journal.pntd.0013206
Interplay of human macrophage response and natural resistance of infection by L. (V.) panamensis to pentavalent antimony
PLOS Neglected Tropical Diseases: published October 6, 2025 | https://doi.org/10.1371/journal.pntd.0013600
Global genomic and antimicrobial resistance profiling of Neisseria gonorrhoeae: Insights from whole genome sequencing and minimum inhibitory concentration analysis
PLOS Neglected Tropical Diseases: published October 6, 2025 | https://doi.org/10.1371/journal.pntd.0013505
NFATc1 regulates LAG3+CD8+ T cells in the spleen of mice infected with Plasmodium yoelii NSM
PLOS Neglected Tropical Diseases: published October 6, 2025 | https://doi.org/10.1371/journal.pntd.0013605
Brugia malayi and other filarial parasite species in animals in areas endemic for lymphatic filariasis in Belitung District, Indonesia
PLOS Neglected Tropical Diseases: published October 7, 2025 | https://doi.org/10.1371/journal.pntd.0013593
Effective strategies for typhoid conjugate vaccine delivery: Health and economic insights from the 2015 Kampala outbreak
PLOS Neglected Tropical Diseases: published October 7, 2025 | https://doi.org/10.1371/journal.pntd.0013566
Designing a multidimensional vulnerability index for supervising dengue cases from 2015 to 2020 in a low/middle-income country: A spatial principal component analysis
PLOS Neglected Tropical Diseases: published October 7, 2025 | https://doi.org/10.1371/journal.pntd.0013556
Distribution of schistosomes and soil-transmitted helminth infections and their association with growth and nutritional status of School-aged children of the Matta health area in the West region of Cameroon
PLOS Neglected Tropical Diseases: published October 7, 2025 | https://doi.org/10.1371/journal.pntd.0013606
The associations between Schistosoma mansoni infection, pre-treatment symptoms, praziquantel side effects, and treatment efficacy in Ugandan school-aged children
PLOS Neglected Tropical Diseases: published October 9, 2025 | https://doi.org/10.1371/journal.pntd.0013167
A review and in silico screening of plant-derived snake venom/toxin inhibitors: ADMET, drug-likeness, and medicinal chemistry profiling
PLOS Neglected Tropical Diseases: published October 9, 2025 | https://doi.org/10.1371/journal.pntd.0013579
Leveraging paired serology to estimate the incidence of typhoidal Salmonella infection in the STRATAA study
PLOS Neglected Tropical Diseases: published October 9, 2025 | https://doi.org/10.1371/journal.pntd.0013612
Modelling the distribution of the tick Ixodes ricinus in England and Wales using passive surveillance data from citizen science reports
PLOS Neglected Tropical Diseases: published October 9, 2025 | https://doi.org/10.1371/journal.pntd.0013520
Transcriptomic analysis reveals that pyruvate kinase potentially plays a key role in the differentiation of Spirometra mansoni proglottids by regulating the glycolysis pathway
PLOS Neglected Tropical Diseases: published October 9, 2025 | https://doi.org/10.1371/journal.pntd.0013570
Barriers to rabies control through mass dog vaccination in rural Uganda: Insights from community perspectives and key informant interviews
PLOS Neglected Tropical Diseases: published October 9, 2025 | https://doi.org/10.1371/journal.pntd.0013578
Effects of pentoxifylline in patients with chronic Chagas cardiomyopathy: A randomized, double-blind, controlled pilot trial
PLOS Neglected Tropical Diseases: published October 9, 2025 | https://doi.org/10.1371/journal.pntd.0013555
Piloting the Schistosomiasis Practical and Precision Assessment approach in five health districts of the N’zérékoré region, Republic of Guinea
PLOS Neglected Tropical Diseases: published October 9, 2025 | https://doi.org/10.1371/journal.pntd.0013413
Medical and health students’ insights into mycetoma: A survey-based study on knowledge and clinical practices
PLOS Neglected Tropical Diseases: published October 9, 2025 | https://doi.org/10.1371/journal.pntd.0013583
Evaluating urban community knowledge, attitudes, and preventive actions (KAP) using the health belief model: Insights from an ideation-informed interpretation of recurrent dengue outbreaks in Selangor, Malaysia
PLOS Neglected Tropical Diseases: published October 10, 2025 | https://doi.org/10.1371/journal.pntd.0013545
Detection of dengue, malaria, and additional causes of acute febrile illness: The need for expanded testing, Bayelsa State, Nigeria
PLOS Neglected Tropical Diseases: published October 10, 2025 | https://doi.org/10.1371/journal.pntd.0013060
Evaluating the efficacy of the praziquantel dose pole for schistosomiasis treatment: A multi-country systematic review
PLOS Neglected Tropical Diseases: published October 10, 2025 | https://doi.org/10.1371/journal.pntd.0013587
Leprosy stigma in the healthcare setting: Lived experiences of persons affected by leprosy in Niger
PLOS Neglected Tropical Diseases: published October 10, 2025 | https://doi.org/10.1371/journal.pntd.0013584
Socioeconomic and ecological drivers of snakebite incidence in Mexico: A spatial analysis of risk factors
PLOS Neglected Tropical Diseases: published October 10, 2025 | https://doi.org/10.1371/journal.pntd.0013582
Epidemiology of ovale, vivax and falciparum malaria in the highlands of Cameroon: An integrated community survey of human infection and vector abundance
PLOS Neglected Tropical Diseases: published October 10, 2025 | https://doi.org/10.1371/journal.pntd.0013549
Lessons from piloting and scaling a real-time DHIS2 based treatment reporting tool for mass drug administration in Nigeria
PLOS Neglected Tropical Diseases: published October 10, 2025 | https://doi.org/10.1371/journal.pntd.0013601
Climatic, socioeconomic, and migratory factors on the epidemiological dynamics of cutaneous leishmaniasis in Colombia, 2007–2021
PLOS Neglected Tropical Diseases: published October 13, 2025 | https://doi.org/10.1371/journal.pntd.0013594
Characterization and ligand binding properties of a fatty acid- and retinol- binding protein (Hp-FAR-2) from Heligmosomoides polygyrus
PLOS Neglected Tropical Diseases: published October 13, 2025 | https://doi.org/10.1371/journal.pntd.0013198
Leprosy relapse after multidrug therapy: Systematic review and meta-analysis
PLOS Neglected Tropical Diseases: published October 13, 2025 | https://doi.org/10.1371/journal.pntd.0011870
Evolution of human leptospirosis in French Guiana, 2016–2022
PLOS Neglected Tropical Diseases: published October 13, 2025 | https://doi.org/10.1371/journal.pntd.0013620
A systematic review and meta-analysis of incidence and spatiotemporal trends of snakebites in Iran
PLOS Neglected Tropical Diseases: published October 14, 2025 | https://doi.org/10.1371/journal.pntd.0013603
Unraveling the drivers of leptospirosis risk in Thailand using machine learning
PLOS Neglected Tropical Diseases: published October 14, 2025 | https://doi.org/10.1371/journal.pntd.0013618
Genetic diversity of Trypanosoma cruzi in individuals with chronic Chagas disease in the Northern Minas Gerais and Vale do Jequitinhonha regions, Minas Gerais, Brazil
PLOS Neglected Tropical Diseases: published October 15, 2025 | https://doi.org/10.1371/journal.pntd.0013627
Community perceptions and practices on hepatic veno-occlusive disease in Tigray, Ethiopia: An explorative study challenging the attribution to Ageratum conyzoides
PLOS Neglected Tropical Diseases: published October 15, 2025 | https://doi.org/10.1371/journal.pntd.0013621
Scorpionism in Brazil: Space-time approach and risk areas in 2012 to 2024
PLOS Neglected Tropical Diseases: published October 15, 2025 | https://doi.org/10.1371/journal.pntd.0013602
Precise staging of severe fever with thrombocytopenia syndrome: Integrating the extent of organ damage for prognostic and therapeutic applications
PLOS Neglected Tropical Diseases: published October 15, 2025 | https://doi.org/10.1371/journal.pntd.0013249
Identification and pathogen screening of ectoparasites from companion animals in urban Vientiane, Lao PDR
PLOS Neglected Tropical Diseases: published October 15, 2025 | https://doi.org/10.1371/journal.pntd.0013625
Seroprevalence and geospatial epidemiology of yaws: Evidence from Ghana
PLOS Neglected Tropical Diseases: published October 16, 2025 | https://doi.org/10.1371/journal.pntd.0013632
Risk assessment and mitigation evaluation of future yellow fever outbreaks under different climate scenarios: Insight from a case study of Brazil
PLOS Neglected Tropical Diseases: published October 16, 2025 | https://doi.org/10.1371/journal.pntd.0013448
Disparities in Global Rabies Burden from GBD 2021: Children, older adults, and low-SDI countries at continued risk
PLOS Neglected Tropical Diseases: published October 17, 2025 | https://doi.org/10.1371/journal.pntd.0013630
Sero-epidemiology of Coxiella burnetii in livestock and humans in Isiolo county Kenya
PLOS Neglected Tropical Diseases: published October 17, 2025 | https://doi.org/10.1371/journal.pntd.0013557
Mitogenomics of the tropical bont tick Amblyomma variegatum reveals vertical and horizontal transmission of Rickettsia africae
PLOS Neglected Tropical Diseases: published October 21, 2025 | https://doi.org/10.1371/journal.pntd.0013610
Age- and sex-associated differences in Lujo hemorrhagic fever pathogenesis in strain 13/N guinea pigs
PLOS Neglected Tropical Diseases: published October 21, 2025 | https://doi.org/10.1371/journal.pntd.0013633
Clinical outcomes of chikungunya across age groups: A systematic review
PLOS Neglected Tropical Diseases: published October 21, 2025 | https://doi.org/10.1371/journal.pntd.0013580
Investigating linkages between human movement and meteorological variables on dengue outbreaks in the Pacific Islands
PLOS Neglected Tropical Diseases: published October 22, 2025 | https://doi.org/10.1371/journal.pntd.0013607
Entomological surveys and insecticide resistance in the dengue vector Aedes aegypti in Dakar, Senegal: First detection of the kdr mutation
PLOS Neglected Tropical Diseases: published October 22, 2025 | https://doi.org/10.1371/journal.pntd.0013657
Geographical distribution of Burkholderia pseudomallei in Taiwanese croplands and the influence of bacterial community interactions on its incubation viability
PLOS Neglected Tropical Diseases: published October 22, 2025 | https://doi.org/10.1371/journal.pntd.0013640
Unveiling immunity dynamics: Serological characteristics of antibodies against Japanese encephalitis virus in Guangdong, China
PLOS Neglected Tropical Diseases: published October 22, 2025 | https://doi.org/10.1371/journal.pntd.0013629
Genomic characterization of eight novel Bartonella species from bats and ectoparasites reveals phylogenetic diversity and host adaptation
PLOS Neglected Tropical Diseases: published October 23, 2025 | https://doi.org/10.1371/journal.pntd.0013646
Investigating cement-based surfaces as a sustainable flooring solution to improve Ascaris Suum egg removal and inactivation in low-resource settings
PLOS Neglected Tropical Diseases: published October 23, 2025 | https://doi.org/10.1371/journal.pntd.0012919
Serologic evidence of crimean-congo hemorrhagic fever virus exposure among livestock and farmers in the Democratic Republic of the Congo
PLOS Neglected Tropical Diseases: published October 24, 2025 | https://doi.org/10.1371/journal.pntd.0013648
Fexinidazole results in specific effects on DNA synthesis and DNA damage in the African trypanosome
PLOS Neglected Tropical Diseases: published October 24, 2025 | https://doi.org/10.1371/journal.pntd.0013647
Induced pluripotent stem cell-derived human macrophages as an infection model for Trypanosoma cruzi
PLOS Neglected Tropical Diseases: published October 24, 2025 | https://doi.org/10.1371/journal.pntd.0012987
Trends and cross-country inequities by region, sex, age in the mortality, incidence, and disability-adjusted life years of COVID-19: Analysis from the Global Burden of Disease Study 2021
PLOS Neglected Tropical Diseases: published October 27, 2025 | https://doi.org/10.1371/journal.pntd.0013642
First field evaluation of novel LDH- and HRP2-based rapid tests for Plasmodium vivax and Plasmodium falciparum malaria diagnosis
PLOS Neglected Tropical Diseases: published October 27, 2025 | https://doi.org/10.1371/journal.pntd.0013307
Neglected brucellosis in pediatric populations from non-endemic regions: Clinical manifestations and prediction of severe disease in Yunnan Province, China
PLOS Neglected Tropical Diseases: published October 27, 2025 | https://doi.org/10.1371/journal.pntd.0013645
Natural salivary gland barrier curtails Zika virus transmission in Thai Aedes aegypti
PLOS Neglected Tropical Diseases: published October 28, 2025 | https://doi.org/10.1371/journal.pntd.0013451
Epidemiologic features and potential year of life lost of scrub typhus in China: A nationwide surveillance analysis (2006– 2023)
PLOS Neglected Tropical Diseases: published October 29, 2025 | https://doi.org/10.1371/journal.pntd.0013666
Antibody response to Aedes aegypti D7L1 + 2 salivary proteins as marker of aggregate vector exposure and correlate of dengue virus susceptibility
PLOS Neglected Tropical Diseases: published October 29, 2025 | https://doi.org/10.1371/journal.pntd.0013099
Spatio-temporal distribution and environmental determinants of dengue vectors in Phnom Penh, Cambodia
PLOS Neglected Tropical Diseases: published October 29, 2025 | https://doi.org/10.1371/journal.pntd.0013667
Prevalence and risk factors of scabies among orphans: A cross-sectional study in Bangladesh
PLOS Neglected Tropical Diseases: published October 29, 2025 | https://doi.org/10.1371/journal.pntd.0013671
Rhesus macaques model human Mayaro virus disease and transmit to Aedes aegypti mosquitoes
PLOS Neglected Tropical Diseases: published October 29, 2025 | https://doi.org/10.1371/journal.pntd.0013061
ADAMTS13 in Bothrops lanceolatus snakebite envenoming: Crude venom-induced reduction of in vitro enzymatic activity and clinical correlation in snakebite patients
PLOS Neglected Tropical Diseases: published October 29, 2025 | https://doi.org/10.1371/journal.pntd.0013678
Adjuvant hyperbaric oxygen therapy reduces the duration of sporotrichosis treatment
PLOS Neglected Tropical Diseases: published October 29, 2025 | https://doi.org/10.1371/journal.pntd.0013659
Trends in the global burden of cystic echinococcosis among children and adolescents from 1990 to 2021: An analysis based on the Global Burden of Disease Study 2021
PLOS Neglected Tropical Diseases: published October 30, 2025 | https://doi.org/10.1371/journal.pntd.0013658
Prognostic model of HIV-associated talaromycosis in south China: A large-scale retrospective study
PLOS Neglected Tropical Diseases: published October 30, 2025 | https://doi.org/10.1371/journal.pntd.0013672
Hidden threats in urban environments: Angiostrongylus cantonensis in Banda Aceh’s cityscape
PLOS Neglected Tropical Diseases: published October 30, 2025 | https://doi.org/10.1371/journal.pntd.0013634
Hantavirus infections and small mammal diversity in Chile: No differences between protected and unprotected areas highlight the need for public health strategies
PLOS Neglected Tropical Diseases: published October 30, 2025 | https://doi.org/10.1371/journal.pntd.0013668
A Trichinella spiralis serine protease triggers gut epithelial apoptosis and destroys the barrier integrity to mediate larval invasion
PLOS Neglected Tropical Diseases: published October 30, 2025 | https://doi.org/10.1371/journal.pntd.0013680
Assessment of vector control strategies based on mass Aedes (Stegomyia) mosquito trapping (AGOs traps) pilot study in a US-Mexico border region of South Texas
PLOS Neglected Tropical Diseases: published October 31, 2025 | https://doi.org/10.1371/journal.pntd.0013665
Engineered Nanobodies for early and accurate diagnosis of dengue virus infection
PLOS Neglected Tropical Diseases: published October 31, 2025 | https://doi.org/10.1371/journal.pntd.0013168
Corrections
Correction: Understanding the role of disease knowledge and risk perception in shaping preventive behavior for selected vector-borne diseases in Guyana
PLOS Neglected Tropical Diseases: published October 6, 2025 | https://doi.org/10.1371/journal.pntd.0013586
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Correction: Knowledge, attitudes and practices of healthcare workers towards noma in Zambezia, Mozambique
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Correction: Development of an automated artificial intelligence-based system for urogenital schistosomiasis diagnosis using digital image analysis techniques and a robotized microscope
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