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Table of Contents

February 2024

Cover

Female Tunga penetrans captured from the hotspots transmission sites for tungiasis. Matharu et al, 2024.

Image Credit: Matharu and colleagues, pntd.0011601

Viewpoints

The use of artificial intelligence to improve mycetoma management

Hyam Omar Ali, Lamis Yahia Mohamed Elkheir, Ahmed Hassan Fahal

A lesion in two: Buruli ulcer and squamous cell carcinoma coexistence

Jessica C. O’Keeffe, Albert H. Yin, Daniel P. O’Brien

Vector-borne pathogen surveillance in a metagenomic world

Koray Ergunay, Brian P. Bourke, Nicole Achee, Le Jiang, John Grieco, Yvonne-Marie Linton

Reviews

Unraveling the role of miRNAs as biomarkers in Chagas cardiomyopathy: Insights into molecular pathophysiology

Heriks Gomes Ribeiro, Ony Araújo Galdino, Karla Simone Costa de Souza, Antonia Pereira Rosa Neta, Hui Tzu Lin-Wang, Edecio Cunha-Neto, Adriana Augusto de Rezende, Vivian Nogueira Silbiger

The importance of estimating the burden of disease from foodborne transmission of Trypanosoma cruzi

Lucy J. Robertson, Arie H. Havelaar, Karen H. Keddy, Brecht Devleesschauwer, Banchob Sripa, Paul R. Torgerson

Progress interrogating TRPMPZQ as the target of praziquantel

Jonathan S. Marchant

Research Articles

Feasibility of post-exposure-prophylaxis with single-dose rifampicin and identification of high prevalent clusters in villages’ hyperendemic for leprosy in Senegal

Gilbert Batista, Pauline Dioussé, Papa Mamadou Diagne, Mahamat Cissé, Ibrahima Tito Tamba, Fatou Diop, Fanta Diop, Lahla Fall, Diama Sakho, Mariama Bammo, Ndiaga Guèye, Christa Kasang, Nimer Ortuño-Gutiérrez, Louis Hyacinthe Zoubi, Madoky Magatte Diop

Metabolomic landscape of macrophage discloses an anabolic signature of dengue virus infection and antibody-dependent enhancement of viral infection

Li Xu, Min Li, Jingpu Zhang, Dongxiao Li, Jie Tao, Fuchun Zhang, Xia Jin, Jiahai Lu, Tiefu Liu

Effect of montelukast in preventing dengue with warning signs among patients with dengue: A multicenter, randomized, double-blind, placebo-controlled trial

Nattapat Nitinai, Worapong Nasomsong, Worayon Chuerboonchai, Akarawin Tweekittikul, Vutthikorn Khingmontri, Bawornnan Panuvatvanich, Thananut Bangchuad, Maynanchaya Pongpraijaroen, Tanapol Roongfa-ngarm, Vasin Vasikasin

Dog ecology and rabies knowledge, attitude and practice (KAP) in the Northern Communal Areas of Namibia

Tenzin Tenzin, Emmanuel H. Hikufe, Nehemia Hedimbi, Rauna Athingo, Mainelo Beatrice Shikongo, Thompson Shuro, Johannes Iipinge, Nelson Herman, Matias Naunyango, Frenada Haufiku, Josephat Peter, Laina Hango, Sara Gottlieb, Kenneth Shoombe, Nicolai Denzin, Frank Busch, Frederic Lohr, Moetapele Letshwenyo, Gregorio Torres, Conrad M. Freuling, Thomas Müller, Albertina Shilongo

Modelling spatiotemporal patterns of visceral leishmaniasis incidence in two endemic states in India using environment, bioclimatic and demographic data, 2013–2022

Swaminathan Subramanian, Rajendran Uma Maheswari, Gopalakrishnan Prabavathy, Mashroor Ahmad Khan, Balan Brindha, Adinarayanan Srividya, Ashwani Kumar, Manju Rahi, Emily S. Nightingale, Graham F. Medley, Mary M. Cameron, Nupur Roy, Purushothaman Jambulingam

Geographic characteristics of HTLV-1 molecular subgroups and genetic substitutions in East Asia: Insights from complete genome sequencing of HTLV-1 strains isolated in Taiwan and Japan

Satoshi Nozuma, Akiko Yoshimura, Shun-Chung Pai, Hung-Jen Chen, Eiji Matsuura, Masakazu Tanaka, Daisuke Kodama, Mika Dozono, Toshio Matsuzaki, Hiroshi Takashima, Ya-Chien Yang, Ryuji Kubota

“Our desire is to make this village intestinal worm free”: Identifying determinants of high coverage of community-wide mass drug administration for soil transmitted helminths in Benin, India, and Malawi

Malvika Saxena, Amy Roll, Judd L. Walson, Emily Pearman, Hugo Legge, Providence Nindi, Chawanangwa Mahebere Chirambo, Angelin Titus, Jabaselvi Johnson, Elijan Abiguël Bélou, Comlanvi Innocent Togbevi, Félicien Chabi, Euripide Avokpaho, Khumbo Kalua, Sitara Swarna Rao Ajjampur, Moudachirou Ibikounlé, Kumudha Aruldas, Arianna Rubin Means

Host gastric corpus microenvironment facilitates Ascaris suum larval hatching and infection in a murine model

Yifan Wu, Grace Adeniyi-Ipadeola, Mahliyah Adkins-Threats, Matthew Seasock, Charlie Suarez-Reyes, Ricardo Fujiwara, Maria Elena Bottazzi, Lizhen Song, Jason C. Mills, Jill E. Weatherhead

Detection of Salmonella Typhi bacteriophages in surface waters as a scalable approach to environmental surveillance

Sneha Shrestha, Kesia Esther Da Silva, Jivan Shakya, Alexander T. Yu, Nishan Katuwal, Rajeev Shrestha, Mudita Shakya, Sabin Bikram Shahi, Shiva Ram Naga, Christopher LeBoa, Kristen Aiemjoy, Isaac I. Bogoch, Senjuti Saha, Dipesh Tamrakar, Jason R. Andrews

Related Articles

Spatial heterogeneity in mass drug administration from a longitudinal epidemiological study assessing transmission interruption of soil transmitted helminths in the Wolaita zone of southern Ethiopia (Geshiyaro Project)

Santiago Rayment Gomez, Rosie Maddren, Ewnetu Firdawek Liyew, Melkie Chernet, Ufaysa Anjulo, Adugna Tamiru, Getachew Tollera, Geremew Tasew, Birhan Mengistu, Benjamin Collyer, Kathryn Forbes, Roy Anderson

Identification and characterization of a novel nematode pan allergen (NPA) from Wuchereria bancrofti and their potential role in human filarial tropical pulmonary eosinophilia (TPE)

Samuel Christopher Katru, Anand Setty Balakrishnan, Gnanasekar Munirathinam, Azadeh Hadadianpour, Scott A. Smith, Ramaswamy Kalyanasundaram

Human risk to tick encounters in the southeastern United States estimated with spatial distribution modeling

Rebecca A. Butler, Mona Papeş, James T. Vogt, Dave J. Paulsen, Christopher Crowe, Rebecca T. Trout Fryxell

Old tools, new applications: Use of environmental bacteriophages for typhoid surveillance and evaluating vaccine impact

Yogesh Hooda, Shuborno Islam, Rathin Kabiraj, Hafizur Rahman, Himadree Sarkar, Kesia E. da Silva, Rajan Saha Raju, Stephen P. Luby, Jason R. Andrews, Samir K. Saha, Senjuti Saha

Related Articles

Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity

Maikel Izquierdo, De Lin, Sandra O’Neill, Lauren A. Webster, Christy Paterson, John Thomas, Mirtha Elisa Aguado, Enrique Colina Araújo, Daniel Alpízar-Pedraza, Halimatu Joji, Lorna MacLean, Anthony Hope, David W. Gray, Martin Zoltner, Mark C. Field, Jorge González-Bacerio, Manu De Rycker

Epidemiology and treatment outcomes of recurrent tuberculosis in Tanzania from 2018 to 2021 using the National TB dataset

Belinda J. Njiro, Riziki Kisonga, Catherine Joachim, Galus Alfredy Sililo, Emmanuel Nkiligi, Latifat Ibisomi, Tobias Chirwa, Joel Msafiri Francis

Elimination of lymphatic filariasis as a public health problem in Malawi

John Chiphwanya, Square Mkwanda, Storn Kabuluzi, Themba Mzilahowa, Bagrey Ngwira, Dorothy E. Matipula, Limbikani Chaponda, Paul Ndhlova, Prince Katchika, Chawananga Mahebere Chirambo, Philemon Moses, Justin Kumala, Martin Chiumia, Carrie Barrett, Hannah Betts, Joan Fahy, Maria Rebollo Polo, Lisa Reimer, Michelle C. Stanton, Brent Thomas, Sian Freer, David H. Molyneux, Moses J. Bockarie, Charles D. Mackenzie, Mark J. Taylor, Sarah Martindale, Louise A. Kelly-Hope

Identification of tungiasis infection hotspots with a low-cost, high-throughput method for extracting Tunga penetrans (Siphonaptera) off-host stages from soil samples–An observational study

Abneel K. Matharu, Paul Ouma, Margaret M. Njoroge, Billy L. Amugune, Ayako Hyuga, Francis Mutebi, Jürgen Krücken, Hermann Feldmeier, Lynne Elson, Ulrike Fillinger

Transmission ecology of Trypanosoma cruzi by Rhodnius prolixus (Reduviidae: Triatominae) infesting palm-tree species in the Colombian Orinoco, indicates risks to human populations

Plutarco Urbano, Carolina Hernández, Natalia Velásquez-Ortiz, Nathalia Ballesteros, Luisa Páez-Triana, Laura Vega, Vanessa Urrea, Angie Ramírez, Marina Muñoz, Carlos N. Ibarra-Cerdeña, Camila González, Juan David Ramírez

Aedes aegypti CCEae3A carboxylase expression confers carbamate, organophosphate and limited pyrethroid resistance in a model transgenic mosquito

Beth C. Poulton, Fraser Colman, Amalia Anthousi, David B. Sattelle, Gareth J. Lycett

Conducting active screening for human African trypanosomiasis with rapid diagnostic tests: The Guinean experience (2016–2021)

Oumou Camara, Justin Windingoudi Kaboré, Aïssata Soumah, Mamadou Leno, Mohamed Sam Bangoura, Dominique N’Diaye, Adrien Marie Gaston Belem, Sylvain Biéler, Mamadou Camara, Jean-Mathieu Bart, Brice Rotureau, Bruno Bucheton

Prevalence and changing antimicrobial resistance profiles of Shigella spp. isolated from diarrheal patients in Kolkata during 2011–2019

Puja Bose, Goutam Chowdhury, Gourab Halder, Debjani Ghosh, Alok K. Deb, Kei Kitahara, Shin-ichi Miyoshi, Masatomo Morita, Thandavarayan Ramamurthy, Shanta Dutta, Asish Kumar Mukhopadhyay

Identification of trans-genus biomarkers for early diagnosis of intestinal schistosomiasis and progression of gut pathology in a mouse model using metabolomics

Peerut Chienwichai, Phornpimon Tipthara, Joel Tarning, Yanin Limpanont, Phiraphol Chusongsang, Yupa Chusongsang, Nuttapohn Kiangkoo, Poom Adisakwattana, Onrapak Reamtong

Clonorchis sinensis on the prognosis of patients with spontaneous rupture of Hepatocellular Carcinoma: An inverse probability of treatment weighting analysis

Hang-Hang Ni, Zhan Lu, Cheng-Lei Yang, Yu-Ting Lv, Chun-Xiu Lu, Bang-De Xiang

Involving patients in drug development for Neglected Tropical Diseases (NTDs): A qualitative study exploring and incorporating preferences of patients with cutaneous leishmaniasis into Target Product Profile development

María del Mar Castro, Astrid C. Erber, Byron Arana, Gláucia Cota, Claudia M. Denkinger, Nicole Harrison, Julia Kutyi, Liliana López-Carvajal, Emma Plugge, Julia Walochnik, Piero Olliaro

Parasites and microorganisms associated with the snakes collected for the “festa Dei serpari” in Cocullo, Italy

Jairo Alfonso Mendoza-Roldan, Livia Perles, Ernesto Filippi, Nicole Szafranski, Gianpaolo Montinaro, Mariaelisa Carbonara, Riccardo Scalera, Pedro Paulo de Abreu Teles, Julia Walochnik, Domenico Otranto

Wait and watch: A trachoma surveillance strategy from Amhara region, Ethiopia

Eshetu Sata, Fikre Seife, Zebene Ayele, Sarah A. Murray, Karana Wickens, Phong Le, Mulat Zerihun, Berhanu Melak, Ambahun Chernet, Kimberly A. Jensen, Demelash Gessese, Taye Zeru, Adisu Abebe Dawed, Hiwot Debebe, Zerihun Tadesse, E. Kelly Callahan, Diana L. Martin, Scott D. Nash

Validation of artificial intelligence-based digital microscopy for automated detection of Schistosoma haematobium eggs in urine in Gabon

Brice Meulah, Prosper Oyibo, Pytsje T. Hoekstra, Paul Alvyn Nguema Moure, Moustapha Nzamba Maloum, Romeo Aime Laclong-Lontchi, Yabo Josiane Honkpehedji, Michel Bengtson, Cornelis Hokke, Paul L. A. M. Corstjens, Temitope Agbana, Jan Carel Diehl, Ayola Akim Adegnika, Lisette van Lieshout

The bloodstream form of Trypanosoma brucei displays non-canonical gluconeogenesis

Julie Kovářová, Martin Moos, Michael P. Barrett, David Horn, Alena Zíková

Quantitative PCR as a marker for preemptive therapy and its role in therapeutic control in Trypanosoma cruzi/HIV coinfection

Vera Lúcia Teixeira de Freitas, Christina Terra Gallafrio Novaes, Ana Marli Christovam Sartori, Noemia Barbosa Carvalho, Sheila Cristina Vicente da Silva, Érika Shimoda Nakanishi, Fernando Salvador, Cleudson Nery de Castro, Rita Cristina Bezerra, Elizabeth Visone Nunes Westphalen, Caroline Medeji Ramos de Oliveira, Felipe Delatorre Busser, Yeh-Li Ho, Renata Buccheri, Carolina Bonilla, Maria Aparecida Shikanai-Yasuda

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Needs assessment of a pythiosis continuing professional development program

Surachai Leksuwankun, Rongpong Plongla, Nathanich Eamrurksiri, Pattama Torvorapanit, Kasidis Phongkhun, Nattapong Langsiri, Tanaporn Meejun, Karan Srisurapanont, Jaedvara Thanakitcharu, Bhoowit Lerttiendamrong, Achitpol Thongkam, Kasama Manothummetha, Nipat Chuleerarux, Chatphatai Moonla, Navaporn Worasilchai, Ariya Chindamporn, Nitipong Permpalung, Saman Nematollahi

Altered IL-7 signaling in CD4+ T cells from patients with visceral leishmaniasis

Shashi Kumar, Shashi Bhushan Chauhan, Shreya Upadhyay, Siddharth Sankar Singh, Vimal Verma, Rajiv Kumar, Christian Engwerda, Susanne Nylén, Shyam Sundar

Immune response after oral immunization of goats and foxes with an NDV vectored rabies vaccine candidate

Magdalena Murr, Conrad Freuling, David Pérez-Bravo, Christian Grund, Thomas C. Mettenleiter, Angela Römer-Oberdörfer, Thomas Müller, Stefan Finke

Mapping the incidence rate of typhoid fever in sub-Saharan Africa

Jong-Hoon Kim, Jungsoon Choi, Chaelin Kim, Gi Deok Pak, Prerana Parajulee, Andrea Haselbeck, Se Eun Park, Vittal Mogasale, Hyon Jin Jeon, Annie J. Browne, Ellis Owusu-Dabo, Raphaël Rakotozandrindrainy, Abdramane Soura Bassiahi, Mekonnen Teferi, Octavie Lunguya-Metila, Christiane Dolecek, Virginia E. Pitzer, John A. Crump, Simon I. Hay, Florian Marks

Benidipine impairs innate immunity converting sublethal to lethal infections in a murine model of spotted fever rickettsiosis

Andrés F. Londoño, Jennifer M. Farner, Marlon Dillon, Dennis J. Grab, Yuri Kim, Diana G. Scorpio, J. Stephen Dumler

Frequent and intense human-bat interactions occur in buildings of rural Kenya

Reilly T. Jackson, Tamika J. Lunn, Isabella K. DeAnglis, Joseph G. Ogola, Paul W. Webala, Kristian M. Forbes

Longitudinal analysis of post-acute chikungunya-associated arthralgia in children and adults: A prospective cohort study in Managua, Nicaragua (2014–2018)

Colin M. Warnes, Fausto Andres Bustos Carrillo, Jose Victor Zambrana, Brenda Lopez Mercado, Sonia Arguello, Oscarlette Ampié, Damaris Collado, Nery Sanchez, Sergio Ojeda, Guillermina Kuan, Aubree Gordon, Angel Balmaseda, Eva Harris

Effects of structurally distinct human HDAC6 and HDAC6/HDAC8 inhibitors against S. mansoni larval and adult worm stages

Roberto Gimmelli, Giuliana Papoff, Fulvio Saccoccia, Cristiana Lalli, Sandra Gemma, Giuseppe Campiani, Giovina Ruberti

MHC-I alleles mediate clearance and antibody response to the zoonotic Lassa virus in Mastomys rodent reservoirs

Ayodeji Olayemi, Dominik Werner Schmid, Ramona Fleischer, Kerstin Wilhelm, Alexander Christoph Heni, Nadine Mueller-Klein, Lavinia Haikukutu, Elisabeth Fichet-Calvet, Stephan Günther, Simone Sommer

Modeling the persistence of Opisthorchis viverrini worm burden after mass-drug administration and education campaigns with systematic adherence

Lars Kamber, Christine Bürli, Helmut Harbrecht, Peter Odermatt, Somphou Sayasone, Nakul Chitnis

Potential selection of antimony and methotrexate cross-resistance in Leishmania infantum circulating strains

Lorena Bernardo, Ana Victoria Ibarra-Meneses, Noelie Douanne, Audrey Corbeil, Jose Carlos Solana, Francis Beaudry, Eugenia Carrillo, Javier Moreno, Christopher Fernandez-Prada

Corrections

Correction: Treatment outcomes among snakebite patients in north-west Ethiopia—A retrospective analysis

Inge Steegemans, Kassaye Sisay, Ernest Nshimiyimana, Gashew Gebrewold, Turid Piening, Endale Menberu Tessema, Birhanu Sahelie, Gabriel Alcoba, Fikre Seife Gebretsadik, Dirk Essink, Simon Collin, Emiliano Lucero, Koert Ritmeijer

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Correction: Ivermectin and doxycycline treatments against Onchocerciasis: Adaptations and impact among semi-nomadic population in Massangam Health District, Cameroon

Rogers Nditanchou, Ruth Dixon, Alexandre Chailloux, Kareen Atekem, Benjamin Biholong, Aude Wilhelm, Richard Selby, Joseph Oye, Joseph Kamgno, Daniel Boakye, Elena Schmidt, Laura Senyonjo

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