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September 2022

The barium enema X-ray image shows a dolichomegacolon of the sigmoid and rectum resulting from Chagas disease. Bierrenbach, et al. (2022)

Image Credit: Dr. Manoel Rocha, Hospital das Clínicas da Universidade de São Paulo

Viewpoints

Drug discovery research in Ghana, challenges, current efforts, and the way forward

Richard Kwamla Amewu, Patrick Amoateng, Patrick Kobina Arthur, Prince Asare, Isaac Asiamah, Daniel Boamah, Isaac Darko Otchere, Cedric Dzidzor Amengor, Edmund Ekuadzi, Kelly Chibale, Susan Jane Farrell, Regina Appiah-Oppong, Dorcas Osei-Safo, Kevin David Read, Ian Hugh Gilbert, Dorothy Yeboah-Manu

Reviews

T-cell receptor variable region usage in Chagas disease: A systematic review of experimental and human studies

Thaiany Goulart de Souza-Silva, Kenneth J. Gollob, Walderez O. Dutra

Review of the neglected tropical diseases programme implementation during 2012–2019 in the WHO-Eastern Mediterranean Region

Supriya Warusavithana, Hoda Atta, Mona Osman, Yvan Hutin

Safety of integrated preventive chemotherapy for neglected tropical diseases

Allan M. Ciciriello, Jessica K. Fairley, Emma Cooke, Paul M. Emerson, Pamela J. Hooper, Birgit Bolton, Genevieve LaCon, David G. Addiss

Research Articles

Diagnostics to support the eradication of yaws—Development of two target product profiles

Noah Fongwen, Becca L. Handley, Diana L. Martin, Camila Beiras, Louise Dyson, Michael Frimpong, Oriol Mitja, Kingsley Asiedu, Michael Marks

Long-term health effects perceived by snakebite patients in rural Sri Lanka: A cohort study

Subodha Waiddyanatha, Anjana Silva, Kosala Weerakoon, Sisira Siribaddana, Geoffrey K. Isbister

The non-glycosylated protein of Toxocara canis MUC-1 interacts with proteins of murine macrophages

Rongqiong Zhou, Hongguo Jia, Zhendong Du, Aiyun Jiang, Zhenhui Song, Tao Wang, Aifang Du, Robin B. Gasser, Guangxu Ma

Health-related quality of life and associated factors among adult podoconiosis patients in Debre Elias district Northwest, Ethiopia

Abraham Abebaw, Asmamaw Atnafu, Nigusu Worku, Asebe Hagos

A baseline epidemiological study of the co-infection of enteric protozoans with human immunodeficiency virus among men who have sex with men from Northeast China

Wei Zhao, Lan Yao, Min Zhuang, Yuan-Long Lin, Xiao-Hong Chen, Li Wang, Bo Song, Ya-Shuang Zhao, Yun Xiao, Feng-Min Zhang, Fu-Xiang Wang, Hong Ling

Laparoscopic resection of hepatic alveolar echinococcosis: A single-center experience

Severin Gloor, Daniel Candinas, Guido Beldi, Anja Lachenmayer

Delayed detection of leprosy cases: A systematic review of healthcare-related factors

Yudhy Dharmawan, Ahmad Fuady, Ida J. Korfage, Jan Hendrik Richardus

Scabies incidence and association with skin and soft tissue infection in Loyalty Islands Province, New Caledonia: A 15-year retrospective observational study using electronic health records

Yves-Marie Ducrot, Enzo Bruno, Jean-Marc Franco, Loïc Raffray, Samuel Beneteau, Antoine Bertolotti

One Health risk challenges and preparedness regarding bovine tuberculosis at abattoirs in North-central Nigeria: Associated drivers and health belief

Ismail Ayoade Odetokun, Nma Bida Alhaji, Jibrin Aminu, Mohammad Kabir Lawan, Madinat Abimbola Abdulkareem, Ibraheem Ghali-Mohammed

Laboratory evaluation of RealStar Yellow Fever Virus RT-PCR kit 1.0 for potential use in the global yellow fever laboratory network

Alison J. Basile, Matthias Niedrig, Amy J. Lambert, Robyn Meurant, Aaron C. Brault, Cristina Domingo, Christin H. Goodman, Barbara W. Johnson, Eric C. Mossel, Mick N. Mulders, Jason O. Velez, Holly R. Hughes

Development, feasibility and potential effectiveness of community-based continuous mass dog vaccination delivery strategies: Lessons for optimization and replication

Christian Tetteh Duamor, Katie Hampson, Felix Lankester, Ahmed Lugelo, Emmanuel Mpolya, Katharina Kreppel, Sarah Cleaveland, Sally Wyke

Urban rats as carriers of invasive Salmonella Typhimurium sequence type 313, Kisangani, Democratic Republic of Congo

Dadi Falay, Liselotte Hardy, Jacques Tanzito, Octavie Lunguya, Edmonde Bonebe, Marjan Peeters, Wesley Mattheus, Chris Van Geet, Erik Verheyen, Dudu Akaibe, Pionus Katuala, Dauly Ngbonda, François-Xavier Weill, Maria Pardos de la Gandara, Jan Jacobs

Strongyloides stercoralis infection induces gut dysbiosis in chronic kidney disease patients

Nguyen Thi Hai, Nuttanan Hongsrichan, Kitti Intuyod, Porntip Pinlaor, Manachai Yingklang, Apisit Chaidee, Thatsanapong Pongking, Sirirat Anutrakulchai, Ubon Cha’on, Somchai Pinlaor

Identification of Aedes aegypti salivary gland proteins interacting with human immune receptor proteins

Edem Gavor, Yeu Khai Choong, Yonghao Liu, Julien Pompon, Eng Eong Ooi, Yu Keung Mok, Haiyan Liu, R Manjunatha Kini, J. Sivaraman

Development and evaluation of an efficient and real-time monitoring system for the vector mosquitoes, Aedes albopictus and Culex quinquefasciatus

Zetian Lai, Jing Wu, Xiaolin Xiao, Lihua Xie, Tong Liu, Jingni Zhou, Ye Xu, Yiquan Cai, Feng Lin, Bin Li, Lu Gan, Anthony A. James, Xiao-Guang Chen

Clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex

Shuo Kan, Qi Li, Hong-Mei Li, Yan-Hua Yao, Xin-Yue Du, Chen-Yun Wu, Guang-Jie Chen, Xiao-Kui Guo, Men-Bao Qian, Zhao-Jun Wang

Visual closed dumbbell-mediated isothermal amplification (CDA) for on-site detection of Rickettsia raoultii

Zheng Gui, Hao Cai, Lin Wu, Qing Miao, Jing feng Yu, Ting Cai, Rui Mao

Epidemiology of infection by pulmonary non-tuberculous mycobacteria in French Guiana 2008–2018

Milène Chaptal, Claire Andrejak, Timothée Bonifay, Emmanuel Beillard, Geneviève Guillot, Stéphanie Guyomard-Rabenirina, Magalie Demar, Sabine Trombert-Paolantoni, Veronique Jacomo, Emilie Mosnier, Nicolas Veziris, Felix Djossou, Loïc Epelboin, French Guiana PNTM working group

Cysteine protease of Clonorchis sinensis alleviates DSS-induced colitis in mice

Xiaoying Xie, Zhanshuai Wu, Yuhong Wu, Jing Liu, Xinyuan Chen, Xiaoqian Shi, Caiheng Wei, Jiasheng Li, Jiahui Lv, Qing Li, Lili Tang, Shanshan He, Tingzheng Zhan, Zeli Tang

Effectiveness of intralesional sodium stibogluconate for the treatment of localized cutaneous leishmaniasis at Boru Meda general hospital, Amhara, Ethiopia: Pragmatic trial

Feleke Tilahun Zewdu, Asressie Molla Tessema, Aregash Abebayehu Zerga, Saskia van Henten, Saba Maria Lambert

The current and future distribution of the yellow fever mosquito (Aedes aegypti) on Madeira Island

José Maurício Santos, César Capinha, Jorge Rocha, Carla Alexandra Sousa

Prolonged delays in leprosy case detection in a leprosy hot spot setting in Eastern Ethiopia

Kedir Urgesa, Naomi D. de Bruijne, Kidist Bobosha, Berhanu Seyoum, Adane Mihret, Biftu Geda, Anne Schoenmakers, Liesbeth Mieras, Robin van Wijk, Christa Kasang, Mirgissa Kaba, Abraham Aseffa

Acceptability measures of water, sanitation and hygiene interventions in low- and middle-income countries, a systematic review

Rose Hosking, Suji Y O’Connor, Kinley Wangdi, Johanna Kurscheid, Aparna Lal

Adverse drug effects among students following mass de-worming exercise involving administration of Praziquantel and Albendazole in KEEA Municipality, Ghana

Wisdom Akrasi, Augustine Suurinobah Brah, Mainprice Akuoko Essuman, Viona Osei, Alex Boye

Vaccine-linked chemotherapy with a low dose of benznidazole plus a bivalent recombinant protein vaccine prevents the development of cardiac fibrosis caused by Trypanosoma cruzi in chronically-infected BALB/c mice

Victor Manuel Dzul-Huchim, Maria Jesus Ramirez-Sierra, Pedro Pablo Martinez-Vega, Miguel Enrique Rosado-Vallado, Victor Ermilo Arana-Argaez, Jaime Ortega-Lopez, Fabian Gusovsky, Eric Dumonteil, Julio Vladimir Cruz-Chan, Peter Hotez, María Elena Bottazzi, Liliana Estefania Villanueva-Lizama

Less is more: Developing an approach for assessing clustering at the lower administrative boundaries that increases the yield of active screening for leprosy in Bihar, India

Nimer Ortuño-Gutiérrez, Pin-Wei Shih, Aashish Wagh, Shivakumar Mugudalabetta, Bijoy Pandey, Bouke C. de Jong, Jan Hendrik Richardus, Epco Hasker

Whole-genome sequencing and genetic diversity of severe fever with thrombocytopenia syndrome virus using multiplex PCR-based nanopore sequencing, Republic of Korea

Jingyeong Lee, Kyungmin Park, Jongwoo Kim, Seung-Ho Lee, Geum-Young Lee, Seungchan Cho, Heung-Chul Kim, Terry A. Klein, Jeong-Ah Kim, Jeewan Choi, Juwan Park, Dong-Hyun Song, Se Hun Gu, Hyeongseok Yun, Jung-Eun Kim, Daesang Lee, Gyeung Haeng Hur, Seong Tae Jeong, Il-Ung Hwang, Won-Keun Kim, Jin-Won Song

How heterogeneous is the dengue transmission profile in Brazil? A study in six Brazilian states

Iasmim Ferreira de Almeida, Raquel Martins Lana, Cláudia Torres Codeço

Cryptosporidiosis outbreaks linked to the public water supply in a military camp, France

Stéphanie Watier-Grillot, Damien Costa, Cédric Petit, Romy Razakandrainibe, Sébastien Larréché, Christelle Tong, Gwenaëlle Demont, David Billetorte, Damien Mouly, Didier Fontan, Guillaume Velut, Alexandra Le Corre, Jean-Christophe Beauvir, Audrey Mérens, Loïc Favennec, Vincent Pommier de Santi

Effectiveness of insecticide thermal fogging in hyrax dens in the control of leishmaniasis vectors in rural Palestine: A prospective study

Samer Sawalha, Amer Al-Jawabreh, Dea Hjaija, Suheir Ereqat, Abdelmajeed Nasereddin, Hanan Al-Jawabreh, Iro Evlampidou

A retrospective clinical, multi-center cross-sectional study to assess the severity and sequela of Noma/Cancrum oris in Ethiopia

Heron Gezahegn Gebretsadik, Laurent Cleenewerck de Kiev

Co-infection of the four major Plasmodium species: Effects on densities and gametocyte carriage

Aurel Holzschuh, Maria Gruenberg, Natalie E. Hofmann, Rahel Wampfler, Benson Kiniboro, Leanne J. Robinson, Ivo Mueller, Ingrid Felger, Michael T. White

Individual and community level predictors of utilization of deworming medications among pregnant women in Ethiopia: A multilevel analysis

Fantu Mamo Aragaw, Daniel Gashaneh Belay, Mastewal Endalew, Melaku Hunie Asratie, Moges Gashaw, Nuhamin Tesfa Tsega

Community-level prevalence of epilepsy and of neurocysticercosis among people with epilepsy in the Balaka district of Malawi: A cross-sectional study

Luise Keller, Dominik Stelzle, Veronika Schmidt, Hélène Carabin, Ann-Kristin Reinhold, Claudius Keller, Tamara M. Welte, Vivien Richter, Action Amos, Lindsay Boeckman, Wendy Harrison, Andrea S. Winkler

A forty-year review of Rocky Mountain spotted fever cases in California shows clinical and epidemiologic changes

Anne M. Kjemtrup, Kerry Padgett, Christopher D. Paddock, Sharon Messenger, Jill K. Hacker, Tina Feiszli, Michael Melgar, Marco E. Metzger, Renjie Hu, Vicki L. Kramer

Related Articles

Pathology and epidemiology of fatal toxoplasmosis in free-ranging marmosets (Callithrix spp.) from the Brazilian atlantic forest

Ayisa Rodrigues Oliveira, Jana M. Ritter, Daniel Oliveira dos Santos, Fabiana Pizzolato de Lucena, Sara Aquino de Mattos, Thaynara Parente de Carvalho, Hannah Bullock, Larissa Giannini Alves Moreira, Izabela Magalhães Arthuso Vasconcelos, Fabíola Barroso Costa, Tatiane Alves da Paixão, Renato Lima Santos

Two snakebite antivenoms have potential to reduce Eswatini’s dependency upon a single, increasingly unavailable product: Results of preclinical efficacy testing

Stefanie K. Menzies, Thea Litschka-Koen, Rebecca J. Edge, Jaffer Alsolaiss, Edouard Crittenden, Steven R. Hall, Adam Westhorpe, Brent Thomas, James Murray, Nondusimo Shongwe, Sara Padidar, David G. Lalloo, Nicholas R. Casewell, Jonathan Pons, Robert A. Harrison

Occurrence of yellow fever outbreaks in a partially vaccinated population: An analysis of the effective reproduction number

Fernanda Cristina da Silva Lopes Ferreira, Luiz Antônio Bastos Camacho, Daniel Antunes Maciel Villela

Study of the migration of Fasciola hepatica juveniles across the intestinal barrier of the host by quantitative proteomics in an ex vivo model

David Becerro-Recio, Judit Serrat, Marta López-García, Verónica Molina-Hernández, José Pérez-Arévalo, Álvaro Martínez-Moreno, Javier Sotillo, Fernando Simón, Javier González-Miguel, Mar Siles-Lucas

Ecology and distribution of Leptospira spp., reservoir hosts and environmental interaction in Sri Lanka, with identification of a new strain

Vincent Sluydts, Siriwardana Rampalage Sarathchandra, Anna Pia Piscitelli, Natalie Van Houtte, Sophie Gryseels, Anne Mayer-Scholl, Nadja Seyhan Bier, Nyo Me Htwe, Jens Jacob

COVID-19 in Africa: Underreporting, demographic effect, chaotic dynamics, and mitigation strategy impact

Nathan Thenon, Marisa Peyre, Mireille Huc, Abdoulaye Touré, François Roger, Sylvain Mangiarotti

Failure to use health services by people with Chagas disease: Multilevel analysis of endemic area in Brazil

Renata Fiúza Damasceno, Ester Cerdeira Sabino, Antonio Luiz Pinho Ribeiro, Ariela Mota Ferreira, Léa Campos de Oliveira-da Silva, Cláudia Di Lorenzo Oliveira, Clareci Silva Cardoso, Thallyta Maria Vieira, Desirée Sant’ Ana Haikal

Distinct loiasis infection states and associated clinical and hematological manifestations in patients from Gabon

Luzia Veletzky, Kirsten Alexandra Eberhardt, Jennifer Hergeth, Daniel Robert Stelzl, Rella Zoleko Manego, Ghyslain Mombo-Ngoma, Ruth Kreuzmair, Gerrit Burger, Ayôla Akim Adegnika, Selidji Todagbe Agnandji, Pierre Blaise Matsiegui, Michel Boussinesq, Benjamin Mordmüller, Michael Ramharter

Hospitalizations due to gastrointestinal Chagas disease: National registry

Ana Luiza Bierrenbach, Nayara Dornela Quintino, Carlos Henrique Valente Moreira, Renata Fiúza Damasceno, Maria do Carmo Pereira Nunes, Nayara Ragi Baldoni, Lea Campos de Oliveira da Silva, Ariela Mota Ferreira, Clareci Silva Cardoso, Desirée Sant’Ana Haikal, Ester Cerdeira Sabino, Antonio Luiz Pinho Ribeiro, Claudia Di Lorenzo Oliveira

Longitudinal monitoring of prevalence and intensity of soil-transmitted helminth infections as part of community-wide mass drug administration within the Geshiyaro project in the Bolosso Sore district, Wolaita, Ethiopia

Toby Landeryou, Rosie Maddren, Santiago Rayment Gomez, Suprabhath Kalahasti, Ewnetu Firdawek Liyew, Melkie Chernet, Hussein Mohammed, Yonas Wuletaw, James Truscott, Anna E. Phillips, Alison Ower, Kathryn Forbes, Ufaysa Anjulo, Birhan Mengistu, Geremew Tasew, Mihretab Salasibew, Roy Anderson

Vivaxin genes encode highly immunogenic, non-variant antigens on the Trypanosoma vivax cell-surface

Alessandra Romero-Ramirez, Aitor Casas-Sánchez, Delphine Autheman, Craig W. Duffy, Cordelia Brandt, Simon Clare, Katherine Harcourt, Marcos Rogério André, Kayo José Garcia de Almeida Castilho Neto, Marta M. G. Teixeira, Rosangela Zacharias Machado, Janine Coombes, Robin J. Flynn, Gavin J. Wright, Andrew P. Jackson

A game-theoretic model of lymphatic filariasis prevention

Jan Rychtář, Dewey Taylor

The role of voltage-gated sodium channel genotypes in pyrethroid resistance in Aedes aegypti in Taiwan

Han-Hsuan Chung, Cheng-Hui Tsai, Hwa-Jen Teng, Kun-Hsien Tsai

Internalization of Leptospira interrogans via diverse endocytosis mechanisms in human macrophages and vascular endothelial cells

Xin Zhao, Jun Guo, Xiaoyuan Jia, Yaling Yang, Lijuan Liu, Weizhong Nie, Zhiqiang Fang

Phylogeographic patterns of the yellow fever virus around the metropolitan region of São Paulo, Brazil, 2016–2019

Marielton dos Passos Cunha, Amaro Nunes Duarte-Neto, Shahab Zaki Pour, Bárbara Brito de Souza Pereira, Yeh-Li Ho, Beatriz Perondi, Jaques Sztajnbok, Venancio Avancini Ferreira Alves, Luiz Fernando Ferraz da Silva, Marisa Dolhnikoff, Paulo Hilário Nascimento Saldiva, Paolo Marinho de Andrade Zanotto

Impact of Shigella infections and inflammation early in life on child growth and school-aged cognitive outcomes: Findings from three birth cohorts over eight years

Elizabeth T. Rogawski McQuade, Rebecca J. Scharf, Erling Svensen, Amber Huggins, Angelina Maphula, Eliwaza Bayo, Ladislaus Blacy, Paula Pamplona E. de Souza, Hilda Costa, Eric R. Houpt, Pascal O. Bessong, Estomih R. Mduma, Aldo A. M. Lima, Richard L. Guerrant

Chromoblastomycosis: A case series from Eastern China

Sujun Liu, Huilin Zhi, Hong Shen, Wenwen Lv, Bo Sang, Qiuping Li, Yan Zhong, Zehu Liu, Xiujiao Xia

A health promotion perspective for the control and prevention of Brucellosis (Brucella melitensis); Israel as a case study

Orna Baron-Epel, Samira Obeid, Dorit Kababya, Shiran Bord, Vicki Myers

Estimating economic and disease burden of snakebite in ASEAN countries using a decision analytic model

Chanthawat Patikorn, Jörg Blessmann, Myat Thet Nwe, Patrick Joseph G. Tiglao, Taksa Vasaruchapong, Tri Maharani, Uyen Vy Doan, Syafiq Asnawi Zainal Abidin, Ahmad Khaldun Ismail, Iekhsan Othman, Suthira Taychakhoonavudh, Nathorn Chaiyakunapruk

Endemic mycoses in South Africa, 2010–2020: A decade-long description of laboratory-diagnosed cases and prospects for the future

Rutendo E. Mapengo, Tsidiso G. Maphanga, Wayne Grayson, Nelesh P. Govender

Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response

Edubiel A. Alpizar-Sosa, Nur Raihana Binti Ithnin, Wenbin Wei, Andrew W. Pountain, Stefan K. Weidt, Anne M. Donachie, Ryan Ritchie, Emily A. Dickie, Richard J. S. Burchmore, Paul W. Denny, Michael P. Barrett

Epidemiological characteristics and spatiotemporal patterns of scrub typhus in Fujian province during 2012–2020

Li Qian, Yong Wang, Xianyu Wei, Ping Liu, Ricardo J. Soares Magalhaes, Quan Qian, Hong Peng, Liang Wen, Yuanyong Xu, Hailong Sun, Wenwu Yin, Wenyi Zhang

IL-4, IL-10, CCL2 and TGF-β as potential biomarkers for severity in Plasmodium vivax malaria

Catalina Tovar Acero, Javier Ramírez-Montoya, María Camila Velasco, Paula A. Avilés-Vergara, Dina Ricardo-Caldera, Miquel Duran-Frigola, Gustavo Quintero, Myriam Elena Cantero, Juan Rivera-Correa, Ana Rodriguez, María Fernanda Yasnot-Acosta

Prevalence and distribution pattern of malaria and soil-transmitted helminth co-endemicity in sub-Saharan Africa, 2000–2018: A geospatial analysis

Muhammed O. Afolabi, Adekola Adebiyi, Jorge Cano, Benn Sartorius, Brian Greenwood, Olatunji Johnson, Oghenebrume Wariri